Biomedical subjects

L N Lavrent'ev

Publications and source records attributed to L N Lavrent'ev.

13 recordsLinked to original sources

PubMed1979

[Characteristics of the occurrence and development of tumors in rats depending on age and the nature of the strontium-90 exposure].

In chronic strontium-90 administration into rats aged 8--10 months osteosarcomas did not develop, while in animals at the age of 3--4 months osteosarcomas incidence was 6.7%. In single injection of the radionuclide in 8--10 months old animals osteosarcomas developed in 2.2% of observations, whereas in 3--4 months old animals--in 45.7%. The most early appearance of osteosarcomas (at the 193d--316th day) was noted in 3--4 months old animals subjected to a single exposure to strontium-90.

Administration, Oral↗

PubMed1977

[Evaluation of the protective effect of Prussian blue, sodium alginate and calcium phosphate according to tumor development after single and chronic exposure to strontium 90 and cesium 137 mixture].

The mixture of radionuclides was employed in the concentrations of 100.0, 400.0 and 0.8, 2.0 mc/rat for strontium-90 and cesium-137 in single and chronic administration correspondingly. Prussian blue, sodium alginate and calcium were employed in amounts of 50 mg, 800 mg and 258 mg per rat a day. The data obtained are correlated with the results of the same experiments without using the protection. In compared doses of the irradiation the protective action of the substances under study was noted only in chronic experiments. In this case, the appearance of malignant neoplasms was nearly twice less, and the survival was 120 days longer. The absorbed doses were decreased by 17 times for cesium-137 in the whole body and nearly by 4 times for strontium-90 in the skeleton.

Alginates↗

PubMed1976

[Blastomogenic effect following single and chronic exposure to a mixture of cesium-137 and strontium-90].

The rate of tumor incidence in different rhythms of rat stomach exposure to cesium-137 and strontium-90 was analysed. The correlative values of the administered nucleids activity were selected by analogy with their content in global natural fall-out. In single exposure to the concentrations of 400 and 100 mc/per rat of cesium-137 and strontium-90 mixture accordingly, osteogenic osteosarcomas developed approximatley 4 times as frequently as in chronic administration of the same radionucleids in concentrations of 2 and 8 mc/per rat, correspondingly.

Adenoma↗

PubMed1971