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Biomedical subjects

L N Mohapatra

Publications and source records attributed to L N Mohapatra.

At least 19 recordsLinked to original sources
PubMed1985

Role of antibodies and effect of BCG vaccination in experimental candidiasis in mice.

The role of humoral antibodies and the effect of BCG vaccination were studied in the experimental candidiasis in mice. The antibody suppressed, B-cell deficient animals were prepared by repeated administration of rabbit anti-mouse-mu-antiserum to the new born mice from birth onwards. Such immunodeficient animals along with controls were infected intravenously with Candida albicans, to study the course of candidal infection. It was observed that B-cell-deficient animals were found to be more susceptible to candidal infection than the controls, as indicated by their steady loss of body weight, longer mean time to death and higher viable counts of candidal cells in different organs. The anti-candidal antibodies were absent in all B-cell-deficient animals but present in the controls. These results suggest that antibodies make a contribution in protection against candidal infection in mice. The BCG vaccinated animals were prepared by repeated intravenous administration of BCG to mice and these vaccinated animals along with unvaccinated controls were challenged intravenously with C. albicans, to study the course of candidal infection. It was observed that BCG vaccination prolonged meantime to death and reduced the number of candidal cells in their kidneys.

Animals↗
PubMed1981

Cerebral cladosporiosis.

Two cases of cerebral abscess caused by Cladosporium bantianum are described. One patient was a 50-year-old man who presented after experiencing symptoms for five years, while the other was a 6-month-old child. In both patients the fungus was identified in the material submitted for histopathological examination, and in 1 case it was cultured. Although no antifungal therapy was administered, the child has improved and is doing well ten months after the operation.

Brain↗