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Biomedical subjects

L N Shcherbacheva

Publications and source records attributed to L N Shcherbacheva.

26 records · Page 2Linked to original sources
PubMedDate not supplied

[Level of R-proteins in blood during development of diabetes mellitus].

R-proteins were studied in children with diabetes mellitus and in the risk group. The highest titre of the pattern was found in the children group where diabetes was the first to be detected. Normalization of the R-proteins high titre after insulin therapy was more typical for patients with first detected diabetes as compared with children impaired by the disease within 1-2 years. Content of immunoreactive insulin and titre of R-proteins correlated in the risk group. Estimation of the R-proteins titre simultaneously with other markers may be used for early diagnosis of diabetes mellitus as well as in control of the disease compensation.

Child↗
PubMedDate not supplied

[Immunoenzyme detection of autoantibodies to the surface of pancreatic islet cells in diabetes mellitus and in increased risk of its development].

The authors described the use of an enzyme-linked immunosorbent assay to determine islet cell surface antibodies (ICSA) in persons at high risk of developing insulin dependent diabetes (IDD) and different types of manifest disease. Among I degree healthy relatives of probands with IDD antibodies were detected in 16%. In disorder of the oral GTT (a small group) ICSA were found in 57% of examinees. In the group of IDD patients which was heterogeneous in duration of disease and age at its onset, the frequency of ICSA was 38%. The least frequency (10%) of antibodies was observed in patients with non-insulin dependent (NIDD) compensated by a diet and oral hypoglycaemic drugs. Among non-compensated NIDD patients 62% were ICSA-positive. Thus, ICSA determined by the enzyme-linked immunosorbent assay, could be employed as a marker of autoimmune damage of the insular apparatus for prognosis of the development of "primary" and "secondary" insulin dependence.

Antigens, Surface↗
PubMedDate not supplied

[Serum immunoglobulins in children with diabetes mellitus].

The authors present the results of studying immunoglobulins of classes A, M, and G in 40 children with diabetes mellitus; immunoglobulin level was analyzed depending on a number of clinical diabetes mellitus indices and insulin antibody titres. The III type of dysgammaglobulinemia was found to be characteristic of patients with microangiopathies; changes in the immunoglobulin content were directly opposite to the changes revealed in patients with microangiopathies. With increasing the duration of diabetes there was an aggravation of dysgammaglobulinemia characteristic of these two groups of patients. The level of immunoglobulins under study was greater in the patients with lipoatrophies and in those without any hereditary predisposition to diabetes than in patients without lipoatrophies and without any hereditary predisposition to diabetes, respectively. A regular reduction of all the immunoglobulins level was observed only in patients with glucosuria of not less than 100 g/24 hours. Immunoglobulin content showed no significant association with the patients' sex, age, the insulin antibody titre, and the age at which diabetes developed, or with hyper cholesterolemia and enlargement of the liver.

Adolescent↗
PubMedDate not supplied

[Clinico-electromyographic characteristics of spinal cord and peripheral nerve function in diabetic children].

By means of stimulating electromyography it was shown that children suffering from diabetes had a decrease in segmental motoneurone stimulation. It was manifested in the in the diminishing ratio of maximum reflex responses of the musculus soleus to the motor ones, in the delay of stimulation recovery, an inhibition of the Achilles tendon reflex. The changes mentioned were less pronounced in children with a history of hypoglycemic comas than in the rest children suffering from diabetes. It is suggested that some of EMG readings (the curve of motoneurone stimulation recovery, duration and asymmetry of the Achilles tendon reflex, rate of nervous impulse transmission may be of value for earlier revealing spinal motoneurone and peripheral nerve injuries in diabetes mellitus.

Action Potentials↗
PubMedDate not supplied

[Spinal cord reflex activity characteristics of children with a diabetic heredity].

Stimulation electromyography has shown that children with hereditary diabetes mellitus develop functional disorders of the spinal cord reflex activity, manifesting in a decrease in correlations between musculus soleus reflex responses and motor ones, the delay of restoration of its segmental motoneuron stimulation, the disturbance of the tendon- and N-reflex supraspinal regulation. The most distinctive sign of these disorders is the curve of segmental motoneuron stimulation recovery. This phenomenon may be valuable for revealing the latent neurological disturbances in persons with diabetes predisposition. It is suggested that the neurological changes revealed may be resultant of the hereditable metabolic specificity.

Adolescent↗