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Biomedical subjects

L Nachury

Publications and source records attributed to L Nachury.

5 recordsLinked to original sources
PubMed1984

Increased plasma concentration of N-terminal beta-lipotrophin and unbound cortisol during pregnancy.

The plasma concentration of N-terminal beta-lipotrophin (beta-LPH), total and protein unbound cortisol, progesterone and the transcortin (CBG) binding parameters have been measured in 21 women in the early follicular phase and in 70 pregnant women at various stages of pregnancy. Results showed that the plasma CBG binding capacity and the concentrations of total cortisol and progesterone increased significantly at each trimester of pregnancy while the plasma concentration of unbound cortisol increased significantly only in the 2nd and the 3rd trimesters of pregnancy. In addition, a significant increase of N-terminal beta-LPH level was observed during the 3rd trimester. By chromatography, it is demonstrated that during the 3rd trimester of pregnancy the beta-LPH/gamma-LPH molar ratio decreases dramatically and that the increase of N-terminal beta-LPH concentration is mainly due to a two fold increase in gamma-LPH concentration.

Female↗
PubMed1984

Acute dopaminergic blockade by sulpiride stimulates beta-endorphin secretion in pregnant women.

The pars intermedia of the pituitary gland is well developed in most animal species but rudimentary in adult human subjects. Unlike the anterior pituitary, the intermediate lobe metabolizes proopiomelanocorticotrophin (POMC) mainly to beta-endorphin and to alpha-melanotrophin (alpha-MSH). This activity of the pars intermedia is under an inhibitory dopaminergic control. Biochemical and immunohistochemical evidence suggests the hyperplasia of the intermediate lobe during human pregnancy. The present study demonstrates that an acute dopaminergic blockade by sulpiride dramatically increases plasma concentrations of beta-endorphin in pregnant women but not in non-pregnant women providing functional evidence for the intermediate lobe hypothesis.

Adult↗
PubMed1984

[Polycystic ovaries. Round table].

Because of the variety and inconstancy of the clinical symptoms, it is difficult to establish a classification of the clinical forms. However, the laboratory profile, essentially a raised serum LH, is fairly constant in every case. The pathophysiology of the disequilibrium of androgen and gonadotrophin secretion can be explained on the basis of various initial functional abnormalities, such as an excess of adrenal androgens or LH or, conversely, a deficiency of FSH. Cystic disease is very common in veterinary medicine and presents a number of specific features. The treatment of polycystic ovaries depends on the symptoms (hirsutism, amenorrhea, sterility). In the case of sterility, inducers of ovulation are effective, but are very difficult to manipulate. A number of authors propose surgical excision (removal of the larger of the two ovaries).

Adrenal Cortex Hormones↗