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Biomedical subjects

L Norgren

Publications and source records attributed to L Norgren.

At least 109 records · Page 6Linked to original sources
PubMed1992

The effect of antimicrobial impregnation on vascular graft healing. An experimental porcine study.

This study evaluates the impregnation of a phenol derivative (Y105) to polymerized Dacron grafts. Y-105 has broad spectrum anti-microbial characteristics. The grafts were inserted end to side in the iliac artery of pigs. Reexploration and graft removal was performed after 7, 14 and 30 days. After pressure fixation with glutaraldehyde the grafts were evaluated for gross morphology and by scanning electron microscopy. A gradual development of pseudo-intima was observed without sign of graft occlusion. The addition of the antimicrobial impregnation did not interfere with healing.

Animals↗
PubMed1992

Compression stockings and venous function in patients with acute myocardial infarction.

Venous volume and venous outflow of the calf were studied in 49 patients with acute myocardial infarction. Graded compression stockings were randomly applied to one leg, the other serving as a control, and the above parameters were studied with strain gauge plethysmography during six days. Venous volume increased in the control legs during the first three days and it was significantly higher in the legs with stockings compared to the control legs throughout the study period. Venous outflow did not change during the study period or with the application of compression stockings. A restricted venous function in the calf may contribute to the initiation of deep vein thrombosis. Graded compression stockings improve the venous function in the leg and may thus reduce the incidence of deep vein thrombosis in patients with acute myocardial infarction. This remains, however, to be proved in a controlled clinical trial.

Adult↗
PubMed1992

Patency after iliac and femoro-popliteal angioplasty. Difference between angiographic and clinical results.

Twenty-five patients with clinical relapse after previous successful angioplasty of iliac or femoro-popliteal arteries were evaluated with repeat angiography. The angiographic patency was 80% despite the clinical symptoms. The discrepancy between the angiographic appearance and the clinical findings was explained by the progress of the general arteriosclerotic vascular disease. Such progression is more important regarding late prognosis than the result of the angioplasty per se.

Aged↗
PubMed1992

Thrombogenicity of gelatine impregnated vascular grafts--an experimental study.

Acute platelet deposition on a knitted Dacron graft impregnated with gelatine to confer zero porosity was compared to a standard knitted Dacron graft. The accumulation of platelets was assessed by reinfusion of 111In labelled platelets and imaging with a scintillation camera. The accumulation of platelets was significantly higher on the sealed grafts at the beginning of the experiments but a steady-state was rapidly achieved and no differences was observed regarding the patency.

Animals↗
PubMed1991

Visceral ischemia following aortic surgery.

Intestinal ischemia after aortic surgery is a rare (1-5%) complication, often with a fatal outcome (greater than 50%). During the period 1974-1987, 554 abdominal aortic operations were performed in our department. 17 patients (3%) were reoperated due to bowel ischemia, ten of these patients died. 12 patients were operated on due to aortic aneurysm (9 emergency operations) and 5 due to occlusive disease. A retrospective analysis of the files of the 17 patients was performed to try to identify the risk patient. Preoperative investigations demonstrated that the inferior mesenteric artery (IMA) was patent in 3 patients and occluded in 5 patients. As to the other 9 patients no information could be found (all with aneurysm). After the primary operation, 11 patients had persistent circulation via at least one of the hypogastric arteries and none of them had persistent circulation via the IMA. 11 patients had bloody diarrhea before reoperation and in 6 patients peritonitis was observed. Rectoscopy was performed in 8 patients and in 7 there was indication of ischemia. The most common finding among the laboratory tests was a rise in the creatinine level which was observed in 10 patients. Other laboratory tests such as blood gases, leucocytes, thrombocytes or temperature were of little predictive value per se. Patients operated on due to ruptured aortic aneurysm are risk patients. No other predictive symptom or sign was found to preoperatively identify the patient at risk for intestinal ischemia. An intraoperative method for evaluating the intestinal blood flow would be of great value when considering selective intestinal vascular reconstruction.

Aged↗
PubMed1990

Dopamine counteracts hypertension during general anesthesia and hypotension during combined thoracic epidural anesthesia for abdominal aortic surgery.

The influence of the degree of sympathetic nervous system activation on the cardiovascular effects of dopamine was studied during abdominal aortic surgery in 13 patients. The arterial plasma norepinephrine concentration (NE) was used as an index of sympathetic nervous system activity. During anesthesia with nitrous oxide and fentanyl, 7 patients (group 1) had a NE above 700 pg/mL and an increased mean arterial pressure (MAP) compared with the preanesthetic level (150 +/- 6 v 117 +/- 10 mm Hg; p less than 0.01, mean +/- SEM). The other 6 patients (group 2) had no significant change in MAP compared with the preanesthetic MAP (119 +/- 7 v 105 +/- 4 mm Hg). Dopamine, 4 micrograms/kg/min, decreased MAP in group 1 by 19% (150 +/- 6 to 121 +/- 8 mm Hg; P less than 0.05) because of a 32% +/- 9% decrease (P less than 0.05) in systemic vascular resistance. MAP was not altered by dopamine in group 2 (119 +/- 7 v 123 +/- 6 mm Hg; not significant). Following termination of dopamine, the anesthetic was supplemented with thoracic epidural anesthesia (TEA). This reduced MAP to 65 +/- 7 mm Hg (P less than 0.01) and 56 +/- 3 mm Hg (P less than 0.01), and NE to 441 +/- 76 (P less than 0.05) and 235 +/- 45 pg/mL (P less than 0.05) in groups 1 and 2, respectively. During TEA, dopamine increased MAP similarly in both groups, to 85 +/- 7 mm Hg (P less than 0.01) and 82 +/- 9 mm Hg (P less than 0.05), respectively. In conclusion, dopamine, at the same dosages, counteracted hypertension during general anesthesia and counteracted hypotension during general anesthesia combined with TEA.

Analysis of Variance↗
PubMed1990

Experimental evaluation of polymerized Dacron grafts in the iliac position of pigs.

Three differently polymerized Dacron grafts were compared to ordinary Dacron grafts and polytetrafluoroethylene grafts in the iliac artery of pigs. The grafts were inserted end-to-side and left for 40 days. Explantation was performed after glutaraldehyde pressure fixation. Gross morphology, light microscopy, and scanning electron microscopy were used to examine the specimens. We concluded that the polymerized grafts behaved similarly to polytetrafluoroethylene grafts and had a very limited foreign body reaction. Endothelial-like cells covered most of the graft surface.

Animals↗
PubMed1990

A stable prostacyclin analogue (iloprost) in the treatment of ischaemic ulcers of the lower limb. A Scandinavian-Polish placebo controlled, randomised multicenter study.

The clinical efficacy of the prostacyclin analogue iloprost was studied during a 2 week treatment and 6 month follow-up period in 103 patients with ischaemic ulcers who were randomised to receive active treatment or placebo. Responders were defined as those patients who achieved healing of at least one third of the ulcer area during the study period. The overall responder rate was 41.3%, compared with 25% for the control group (P = 0.086). Side effects including flushing and headache, were common. The study population had a mortality of 23% during the 6 month period, the amputation rate was 43.5% for iloprost and 50% for placebo treated patients. In this severely diseased population of patients a treatment period limited to 2 weeks did not sufficiently improve ulcer healing.

Adult↗
PubMed1990

Thrombogenicity of metallic vascular stents in arteries and veins--an experimental study in pigs.

Endovascular expanding metallic stents were percutaneously implanted in the iliac arteries and veins of pigs. The vessels had been stenosed by a ligature of catgut 4 weeks prior to this. Platelets were labeled with Indium 111 and the deposition onto the dilated and stented areas was dynamically registered for 240 min with a scintillation camera. All six arterial and six venous stents remained patent throughout the examination period. At the site of arterial stenting there was an increase, of deposited activity, and in the veins a decrease. These experimental findings support the use of endovascular stents after dilation, especially in venous stenoses.

Angioplasty, Balloon↗