Biomedical subjects
L O Ivanishvili
Publications and source records attributed to L O Ivanishvili.
[Hemodynamic effect of foridon and nifedipine at rest and during exercise].
In an acute experiment, hemodynamic effects of ryodipine, 30 mg, were compared with those of nifedipine, 30 mg, in 22 patients with circulatory failure at rest (n = 22) and during bicycle ergometer exercise testing (n = 10). During exercise, the two drugs significantly increased the maximal cardiac index values. Ryodipine induced no increment in elevated pulmonary diastolic pressure, whereas nifedipine significantly diminished the increase. Total pulmonary resistance increased during the initial load exercise, remained unaltered with ryodipine, while nifedipine decreased this parameter in response to the load exercise. Thus, hemodynamic effects of ryodipine and nifedipine were similar at rest, the latter drug being more efficient during exercise. The effects of the drugs in question were similar to those of peripheral arteriolar vasodilators such as hydralazine.
[Quantitative evaluation of disorders of total and regional contractile function in patients with left ventricular postinfarct aneurysm using computed 2-dimensional echocardiography].
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[Effect of intravenous administration of nitroglycerin on the indicators of central hemodynamics in patients with acute myocardial infarction].
The effect of intravenous nitroglycerin administration on central hemodynamics criteria (end diastolic pressure in the pulmonary artery and cardiac output) was analysed in a controlled study of 60 patients with acute myocardial infarction. Nitroglycerin-induced changes in the parameters were shown to be related to the hemodynamic state at baseline, with the improvement in left ventricular functional state being significant in the presence of left ventricular insufficiency and the changes minimal in the presence of normal baseline parameters. Thus, nitroglycerin can be used in patients with hemodynamic alterations without a detrimental effect.
[Echocardiographic evaluation of the effect of nitroglycerin on the functional state of the left ventricle in patients with acute myocardial infarction].
The authors studied the influence of intravenously administered nitroglycerin on the general and local contractile function of the left ventricle with the aid of ultrasound examination of the heart and measurement of the end diastolic pressure in the left pulmonary artery by balloon Swan-Hanz catheters. A group of 56 patients with transmural myocardial infarction was examined: 33 during the acute period of disease received nitroglycerin, 23 patients constituted the control group. Intravenous administration of nitroglycerin shows decrease in the end diastolic and end systolic volumes, mean arterial pressure, in the end diastolic pressure of the pulmonary artery and increase in the cardiac output. The control group did not show such statistically significant changes. Only 33 patients with myocardial infarction of lower localization myocardial movements in the affected area were observed. No such thing was seen in the control group. In the treated group significant decrease in the end systolic and end diastolic pressures were recorded and also increase in the output fraction and so remained up to the 7th day of the disease as compared to the control group.
[Effect of nitroglycerin treatment on left ventricular contractile function in the acute period of myocardial infarct].
The effect of intravenously injected nitroglycerin on the left ventricular contractile function was studied in 17 patients during the first day of transmural myocardial infarction using uni- and two-dimensional ultrasound technique. The data obtained demonstrated a positive time course of some of the main characteristics of the left ventricular contractile function: a decreased end-diastolic and end-systolic left ventricular volume, and an increased ejection fraction. The local contractile function of injured and intact segments of the myocardium increased only in a few of cases observed.
[Comparative characteristics of the physical, x-ray and hemodynamic data in assessing heart failure in myocardial infarct].
The physical and X-ray findings in 103 patients with acute myocardial infarction were compared with the value of left-ventricular filling pressure (LVFP). The LVFP was determined from the level of end diastolic pressure in the pulmonary artery determined by means of a balloon catheter. On the whole, the congruence was revealed between the X-ray findings and the LVFP. A still more definite picture may be obtained of the LVFP value if the results of physical examination are considered in addition to the X-ray data. At the same time, a disparity arises in some cases between the information obtained by means of catheterization of the pulmonary artery on the one hand and the physical and X-ray methods on the other. This must be borne in mind in applying intensive therapeutic measures, e. g. in cases with acute left-ventricular insufficiency, because erroneous therapeutic tactics may be chosen due to "post-therapeutic delay" of the physical and X-ray symptoms.