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Biomedical subjects

L O Kallings

Publications and source records attributed to L O Kallings.

13 recordsLinked to original sources
PubMed1979

Penetration of ampicillin into urethral and cervical secretions after oral administration of bacampicillin.

The study comprised 24 male and 24 female patients treated either for uncomplicated gonorrhoea or as a prophylaxis. A single dose of 800 mg of bacampicillin + 1.0 g probenecid was administered orally to each patient. The concentrations of ampicillin in urethra and cervix were assayed by means of alginate swabs that were used as diffusion centres on agar diffusion plates. The inhibition zones were compared with a standard series of swabs containing known amounts of ampicillin. The amounts of secretions absorbed into the swabs were determined by weighing each swab before and after taking the specimen. The median ampicillin concentration in the male urethra one hour after the single dose of bacampicillin plus probenecid was 2.0 micrograms/ml of urethral secretion and increased to 3.2 micrograms/ml two hours after administration of the antibiotic. In the female urethra, the median concentrations of ampicillin were 1.5 micrograms/ml and 2.3 micrograms/ml of urethral secretion one and two hours, respectively, after the same dosage as above. The corresponding ampicillin concentrations in the cervical secretion were 1.6 micrograms/ml and 2.9 micrograms/ml, respectively.

Administration, Oral↗
PubMed1979

A dose response study with bacampicillin in uncomplicated gonorrhoea.

In a systematic study of dose-response relationship 883 patients with uncomplicated gonorrhoea were given single oral doses of 400, 800 or 1600 mg bacampicillin, with 1 g probenecid. A single dose of bacampicillin 800 mg plus probenecid was the minimum effective dose in patients with fully ampicillin-sensitive strains. In patients with gonococci showing reduced sensitivity to ampicillin, 1600 mg bacampicillin was required to reach a cure rate above 95%. Bacampicillin was well tolerated in all treatment groups. Side-effects were reported in 4.6% of the courses of treatment. The most frequent adverse reaction was loose stools (1.9%), which was noted more often after the 1600 mg dose but was considered to be of no or very little clinical importance.

Administration, Oral↗
PubMed1977

An epidemic of Salmonella typhimurium infection among aircraft passengers.

In February 1976 an outbreak of gastroenteritis occurred among 819 aircraft passengers to and from Gran Canaria. 360 of them had gastroenteritis and 88 were hospitalized. Fecal specimens were collected from 710 of the passengers and 344 of them were positive for Salmonella typhimurium phage type 15. Food served on the flight was the source of infection. The repeated incidences of this kind support the necessity of laying down rules and recommendations for the control of air catering services.

Aircraft↗
PubMedDate not supplied

Rules and regulation.

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Drug Contamination↗