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Biomedical subjects

L O Lamke

Publications and source records attributed to L O Lamke.

At least 19 recordsLinked to original sources
PubMed1993

Absence of Helicobacter pylori in dental plaques in Helicobacter pylori positive dyspeptic patients.

To test the validity of reports on detection of Helicobacter pylori in the mouth, samples were obtained simultaneously from the gastric mucosa and dental plaques for culture in 94 patients examined consecutively by endoscopy. Histological examinations and serological tests were also performed. Helicobacter pylori was not found in the mouth of any of the patients including 52 who had culture-positive gastric biopsies. Thus earlier results could not be confirmed, however, other techniques such as the polymerase chain reaction might give different results.

Adult↗
PubMed1990

Severity and location of venous valvular insufficiency: the importance of distal valve function.

Venous calf pump function was evaluated with special reference to distribution and severity of deep venous reflux at different levels. A combination of ultrasonography, foot volumetry and venous plethysmography was used in 100 consecutive patients, 32 of whom were also studied with phlebography and intravenous pressure measurements. A clear relationship was found between clinical stage of chronic venous insufficiency and number of segments with reflux. Clinically important deep venous insufficiency was found particularly in patients with reflux in the distal posterior tibial veins, even in the presence of competent popliteal valves. The results demonstrated the calf pump to be functionally divided into a series of pumps, with the distal part more important than the proximal. The importance of evaluating venous valvular function at different levels for adequate assessment of venous calf pump function is emphasized.

Adult↗
PubMed1985

Follow-up of 102 patients operated on for gastrointestinal carcinoid.

A series of 102 patients with carcinoid tumor is reviewed. The sites of carcinoid were stomach (1 case), appendix (32), small intestine (57) and colon or rectum (12). The average age was 37 years in the patients with appendiceal carcinoid and 62 years in the others. The mean observation time was 9.2 years in appendiceal carcinoid, and none of these patients died of the tumor. Among the patients with carcinoid in other sites, the 5-year survival rate was 65%. Only patients initially free from metastases were still alive after 12 years. Multiple synchronous carcinoid tumors were found in 14 cases, all of them men. The investigation illustrated the difficulties in preoperative diagnosis of carcinoid, including the small value of laboratory tests. A positive attitude to exploratory laparotomy is therefore recommended. When no or only a few lymph-node metastases are found at intendedly curative operation, a "second look" exploration six months after the primary operation will probably reveal any recurrence and can lead to radical removal of this slow-growing tumor. When distant metastases are present, the long-term outlook is poor. The reason why only men had multiple synchronous carcinoids was not clear from our study.

Adolescent↗
PubMed1981

LCEC analysis of 5-hydroxytryptamine and norepinephrine in the human gastrointestinal tract.

The mucosal content of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) in different parts of the human gastrointestinal tract has been studied. Peroperative biopsies of normal mucosa were collected during various gastrointestinal operations. The amines were extracted and assayed by liquid chromatography with electrochemical detection (LCEC). The concentration of 5-HT was generally approximately 12 times higher than the NE concentration and the highest concentration for both amines was observed in the duodenum, 14 micrograms/g and 1.5 micrograms/g wet weight for 5-HT and NE respectively.

Chromatography, Liquid↗
PubMed1980

The influence of elevated body temperature on skin perspiration.

To evaluate the influence of an elevated rectal temperature on sensible and insensible perspiration the evaporative water losses from the skin of 33 female and 41 male surgical patients with fever were recorded with an evaporimeter. It was found that the patients were generally in a state of normal insensible perspiration. In some of the patients, however, intermittent sensible sweating was observed. In all cases when the patients were sweating the rectal temperature was above 39.5 degrees C and the cutaneous water loss was increased 6-8 times over basal values. The sweating periods, however, took place only during 4-7 hours per 24-hour period in an ambient temperature of about 23.5 degrees C. This means that in a comfortable indoor environment an extra 600 ml per day of fluid should be supplied to patients with highly elevated body temperature in order to compensate for an increased cutaneous water loss. In a tropical or subtropical climate the extra fluid supply has to be substantially increased.

Female↗
PubMed1980

Is albumin therapy worthwhile in surgery for colorectal cancer?

Patients with colorectal cancer undergoing elective surgery with resection of the tumour and primary anastomosis were randomly allocated into two groups. 29 patients received a total of 60-75 g of albumin postoperatively, 30 patients received no albumin and served as controls. The two groups were comparable with respect to age and sex of the patients and stage of growth of the tumour. The patients who received albumin had a significantly lower preoperative serum albumin concentration. On day 4 after the operation the serum albumin concentrations of the control patients and the patients who received albumin were 20% and 5% lower, respectively, than the preoperative value. Eight patients of the albumin group and 5 of the control group developed postoperative complications. There was no significant difference in the postoperative clinical course between the two groups. Preoperative serum albumin levels did not differ between patients who developed postoperative complications and those who had an uneventful postoperative course whether or not they received albumin postoperatively. The present study does not confirm earlier results indicating that serum albumin alone is of prognostic value for the postoperative course following colorectal surgery. Furthermore, the postoperative course is not improved by addition of albumin postoperatively and hence albumin should be given in this situation only when its specific oncotic effect is required.

Adult↗
PubMed1979

Warm dry air treatment of 345 patients with burns exceeding 20 per cent of the body surface.

Two groups of patients with burns covering more than 20% of the body surface treated in a warm dry environment in two Burn Units in Sweden have been compared. The methods of treatment of the 345 patients were almost identical, using plasma and crystalloid solutions during the period of early intense therapy, use of frequent bathing and early debridement of the necrotic burned tissue and application of homo- or heterograft skin prior to the transplantation of autograft skin. The percentage mortalities in the two groups of patients (15.7% and 20.2%) were not significantly different, neither were the causes of the burn or the cause of death. Combination of the results and probit analysis did however show that treatment in a warm dry environment was associated with a lower rate of mortality in patients with very extensive burns than found in other studies not using these environmental conditions in Sweden prior to 1968 (by the same authors) in the United Kingdom and in the United States of America.

Adolescent↗
PubMed1979

Treatment of pilonidal sinus by radical excision and reconstruction by rotation flap surgery of Z-plasty technique.

Defects after excision of large pilonidal sinuses were reconstructed by either rotation skin flaps or a Z-plasty technique. Altogether, 16 patients were operated on, 10 with a rotation flap and 6 with a Z-plasty technique. All the patients except one underwent a radical operation. The patient not having a radical operation had a recurrence. Two cases in the Z-plasty groups acquired an infection in the distal part of the wound necessitating reoperation on the resultant sinus. The disability after this more extensive surgery was not more pronounced than after ordinary surgical procedures. For large recurrent pilonidal sinuses, radical excision and primary suturing of the wound using a rotation flap is recommended as the method of choice.

Adult↗
PubMed1979

Intrathoracic goitre: a review of 29 cases.

Twenty-nine patients suffering from intrathoracic goitre who were admitted to a thoracic surgical clinic were studied. Most patients had respiratory complaints but as many as 28% did not have any symptoms and their goitres were revealed on routine chest X-rays. Only seven patients were operated upon with a thoracic approach, usually a sternal split. All others were operated upon with a cervical collar incision. Three of the goitres were toxic and one malignant. Two of the patients died, one when inducing anaesthesia and the other of pulmonary embolism six days after the operation. General anaesthesia with endotracheal intubation is preferred when operating for intrathoracic goitre. The operation is started with a cervical collar incision and the patients prepared for a sternal split. Lateral thoracotomy may be necessary only when the mass is situated in the posterior mediastinum.

Aged↗
PubMed1978

Abdominal paracentesis for early diagnosis of closed abdominal injury.

In a 4 year material of closed abdominal injuries consisting of 114 patients, mostly multiple trauma traffic accidents, diagnostic paracentesis with peritoneal lavage was used in 47 cases. The aim of the investigation was to indicate or exclude blood in the abdominal cavity as early as possible and thereby facilitate the priority of treatment and diminish the delay in surgical intervention. The main indication was suspicion of abdominal injury in multiple traumatized, unconscious or shocked patients. The puncture was performed in the emergency room immediately after ordinary lifesaving steps had been taken. If blood was obtained the patients were sent to the operating theatre for laparotomy. If blood was not obtained one litre of an isotonic salt solution was infused and if the returning solution was only slightly blood tinged, the investigation was continued with roentgenographic methods. In our series only two cases were not correctly diagnosed. Diagnostic paracentesis is the most rapid method of demonstrating intraabdominal bleeding, which is found in 90% of all serious intraabdominal organ injuries. In doubtful cases this method must be combined with other diagnostic methods and the patient put under proper clinical observation.

Abdominal Injuries↗
PubMed1977

Insensible perspiration from the skin under standardized environmental conditions.

The cutaneous insensible perspiration of adult healthy volunteers was measured by a new method based on estimation of the vapour pressure gradient in the air layer immediately adjacent to skin. All measurements were performed at ambient temperatures of 22 degrees, 27 degrees and 30 degrees C and at a relative humidity of 30%. On the basis of the results obtained the total body surface area of the investigated subjects was divided into four different zones with respect to quantitative water loss. The percentage contribution of the different zones to the total cutaneous water loss proved to be fairly independent of the amibent temperature. The average total cutaneous insensible perspiration of a naked resting subject with a body surface area of 1.75 m2 was estimated to be 381 +/- 18, 526 +/- 25 and 695 +/- 35 ml per day (mean values +/- SEE) at an ambient temperature of 22 degrees C, 27 degrees C and 30 degrees C, respectively. By recording the evaporation rate from only three separate measurement points, it was possible to calculate the total cutaneous insensible water loss with good accuracy.

Adolescent↗
PubMed1977

Water loss by evaporation from the abdominal cavity during surgery.

During abdominal surgery of different degrees of severity the evaporative water loss from wounds and exteriorized bowels was measured by recording the rate of vapour concentration increase in a closed measuring chamber placed over the exposed abdominal cavity. In an animal experiment on 4 rabbits the excessive evaporation of water from exteriorized bowels (15 g/h) gradually decreased and stabilized at approximately 50% of the initial value after 20 min of exposure. In surgical patients the loss by evaporation from a minor incision with only slightly exposed viscera was only 2.1 +/- 0.5 g/h, while moderate incisions with partly exposed but non-exteriorized intestines showed a loss of 8.0 +/- 1.0 g/h. During major exposure with exteriorized bowels a profuse evaporation of 32.2 +/-2.9 g/h was recorded. This evaporation constitutes an additional water loss of a magnitude exceeding the total cutaneous perspiration of healthy adults at rest. Simultaneously the surface temperature of exposed bowels fell by 3.5 degrees C. The evaporative water loss from abdominal exposures is of clinical importance only in time-consuming procedures comprising exposure and exteriorization of the intestines.

Abdomen↗