PubMed Health⌕ Search

Biomedical subjects

L O Nordberg

Publications and source records attributed to L O Nordberg.

3 recordsLinked to original sources

Carbon dioxide angioscopy.

Endovascular intervention has become an increasingly more popular method of diagnosing and treating vascular disease. Its expanding scope includes applications ranging from visualization of the peripheral vascular system to coronary artery interventions. This trend is primarily a result of the limitations of angiography, the current imaging standard, when compared to angioscopy. Multiple disease entities, including atherosclerotic plaque, embolic debris, and thrombus, can not be differentiated between based on angiographic appearance. Angioscopy is a more sensitive method of distinguishing between the above disease states by allowing direct visualization of the luminal surface. The significance of this distinction lies in the fact that the treatment options are notably different based upon the diagnosis. Yet another advantage of angioscopy is its therapeutic value in addition to its diagnostic abilities. Directed embolectomy, guide-wire or catheter placement, or pseudointimal resection are all possible through the angioscope at the time of diagnosis.

Journal Article↗

The relationship between vessel wall tension and the magnitude and frequency of oscillation in rat aorta.

Aortic rings from adult normotensive rats display spontaneous rhythmic activity that is enhanced by vasoconstricting agents. Graded doses of norepinephrine as well as combinations of norepinephrine and vasodilators produced levels of tension that were inversely related to the magnitude of oscillation and directly related to the frequency. A similar result occurred with KCl stimulation. Oscillations were only slightly affected by removal of the endothelium. These results, when combined with other reported studies, suggest that the oscillations in rat aorta are a manifestation of feedback control that may involve the cyclic release of one or more agents affecting calcium channels.

Animals↗

Determination of the drug-receptor dissociation constant of endothelin-1 using photorelaxation of rabbit isolated thoracic aorta.

An in vitro preparation of rabbit thoracic aorta was tested in order to determine whether isometric contractile force induced by endothelin-1 (ET-1) in this preparation is changed when the tissue is exposed to ultraviolet (UV) light. After constriction of an aortic segment to a steady-state level of tension with ET-1, a flash of UV light induced a transient decrease in tension that returned exponentially to equilibrium. This response was endothelium-independent and sensitive to the extracellular sodium concentration. The rate of return to the baseline tension after photorelaxation increased with increasing concentrations of ET-1. UV light had only a slight photorelaxing effect at very low and very high ET-1 concentrations and a much larger effect at concentrations near the A50 value of ET-1. Since an irreversible antagonist does not yet exist for ET-1, the partial irreversible blockade method for getting the dissociation constant (KD) functionally was not possible. The relaxation method, using UV light as a perturbation of ligand-receptor equilibrium, was used instead to obtain KD as well as the forward (k1) and reverse (k2) rate constants of ET-1 in this tissue.

Animals↗