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Biomedical subjects

L O Persson

Publications and source records attributed to L O Persson.

27 records · Page 2Linked to original sources
PubMed1987

Mood and somatic symptoms.

The relations between subjective ratings of mood and somatic symptoms were examined in four studies. Correlational analysis revealed strong relations both between and within the different aspects of mood and somatic discomforts. It was also found that the more diffuse somatic discomforts showed the highest correlations with mood. A time-series analysis also revealed that the dominating explanatory factor was from current symptom reports to current mood reports and not vice versa.

Adult↗
PubMed1985

An oral and psychosocial examination of patients with presumed oral galvanism.

The present investigation was performed to elucidate possible etiological factors behind the complaints reported by 62 patients referred because of presumed oral galvanism. Twenty-nine patients, matched with a subsample of the test group regarding age and sex, comprised a control group. The patients were examined regarding oral medical and stomatognathic health. Their psychological and social health and symptoms were evaluated by means of a standardised interview and 5 self-rating questionnaires. A complex symptomatology including symptoms from both the oral regions and other parts of the body constituated the most distinctive feature of the patients in the test group. The clinical examination as well as patient-perceived symptoms revealed high prevalences of parafunction and dysfunction in the muscles of the stomatognathic system. Furthermore, general complaints were mainly related to muscles of the extremities, and diseases of the joints and muscles were the most commonly reported disorder. The findings at the oral medical examination revealed no differences between the groups, except for signs of parafunction. Patients in the test group gave evidence of being more exposed to negative social events and the results clearly indicate a psychogenic component behind the reported complaints.

Electrogalvanism, Intraoral↗
PubMed1980

Mood effects of diazepam and caffeine.

Changes in mood after administration of Diazepam and Caffeine were analyzed. Six aspects were studied: pleasantness, activation, extraversion, calmness, social orientation and control. In addition to this check list, mood ratings using magnitude estimation of selected adjectives were obtained. It was found that Diazepam decreased feelings of activation and extraversion and increased calmness. Caffeine had no clear effects on the check list, but on the magnitude estimation scale some effects opposite to those of Diazepam were observed. Men reported a higher degree of pleasantness than women after administration of Diazepam. No differences in heart rate were found. Few distinct scale values were utilized on the magnitude estimation scale and the discriminative power was found to be larger for the check list than for the magnitude estimation scale.

Adult↗
PubMed1980

Mood effects of alcohol.

Doses of 0.41, 0.63, and 0.85 g alcohol/kg body weight were administered using a double-blind Latin square design to subjects who made mood ratings at seven points in time during 3h subsequent to administration. The subjects felt more euphoric and extraverted and less tense at mainly the highest dose levels. Lower dose levels tended to induce more negative feelings. Frequent consumers of alcohol derived greater affective benefit than rare drinkers. Intercorrelations between ratings of subjective intoxication and mood variables indicated that the meaning of the variable "subjective intoxication" was different for the three dose levels and for different points in time.

Adult↗
PubMedDate not supplied

Citrate synthase 1 interacts with the citrate transporter of yeast mitochondria.

We have previously shown that citrate synthase binds to an intrinsic protein of the mitochondrial inner membrane (D'Souza and Srere, 1983). In this paper we present evidence that this citrate synthase binding protein is the citrate transporter. We have used citrate synthase 1 mutants of Saccharomyces cerevisiae and transformants containing citrate synthase inactivated by site-directed mutagenesis to study the effect of the CS1 protein upon mitochondrial function (Kispal and Srere). In the present study citrate uptake and oxidation were measured during state 3 conditions (presence of 200 microM ADP) in the mitochondria of several strains of Saccharomyces cerevesiae: a parental strain containing wild-type mitochondrial citrate synthase (CS1) and strains derived from a CS1 deficient strain in which the CS1 gene was disrupted by insertion of the LEU2 gene. These strains were generated from the CS1- cells by transformation with vectors encoding site-specific mutants of CS1 possessing very low levels of enzymatic activity. One such strain in this study was subsequently found to have undergone reversion to produce a strain which had activity very similar to wild type. Positive correlation between citrate uptake and the rate of citrate oxidation was found, suggesting coupling of the two processes. Both mitochondrial citrate uptake and oxidation were decreased in the mutant lacking any form of CS1 protein. Reintroduction of mutagenized CS1 into yeast causes an enhancement in the rate of state 3 oxygen consumption and of citrate uptake.(ABSTRACT TRUNCATED AT 250 WORDS)

Carrier Proteins↗
PubMedDate not supplied

Immunological mapping of fine molecular surface structures of citrate synthase enzymes from different cell types.

Citrate synthase (EC 4.1.3.7), which is present in all living organisms as a key enzyme in aerobic energy metabolism, is one of the most highly phylogenetically conserved enzymes known in terms of its primary and active site structure. However, in terms of other parameters such as in vitro stability, tolerance to changes in pH, degree of self-polymerization, etc., citrate synthases from different sources are markedly different. These divergences can be observed even between isoforms of the enzyme within the same species. Data documenting these diversities suggest that a high degree of difference in tertiary structures may occur. Therefore, the surface profiles of citrate synthase enzymes from yeast, pig, rat, tomato and Escherichia coli were investigated with immunological methods using monoclonal antibody families generated against either pig citrate synthase (alpha-PCS) or yeast citrate synthase-2 (alpha-YCS-2). A high degree of homology of enzyme epitopes was detected on the mitochondrial citrate synthases originating from yeast, tomato, pig and rat cells. Major differences were found between the hexameric citrate synthase originating from E. coli compared with those dimeric forms prepared from eukaryotic cells. Only modest similarities were detected between the highly homologous peroxisomal and mitochondrial yeast citrate synthases. Furthermore, a point mutation of one of the catalytic residues (H274R on recombinant pig and H313R on yeast enzyme) of mitochondrial citrate synthase (CS-1) resulted in a significant increase in immunological similarity with the peroxisomal isoenzyme (CS-2). These findings are discussed in terms of the possible mechanism of evolution of CS-2 in yeast.

Animals↗
PubMedDate not supplied

The development of emotional distress in 158 patients with recently diagnosed rheumatoid arthritis: a prospective 5-year follow-up study.

OBJECTIVES: To describe the development of emotional distress among patients with newly diagnosed rheumatoid arthritis (RA), and to explore for early predictors of elevated distress over time. METHODS: The study group consisted of 158 early RA patients (64% females) with mean age of 51.4 (SD = 12.7) years at disease onset. The patients were evaluated once a year for up to at least 4 years after baseline. Emotional distress was measured with the Symptom Checklist (SCL-90), disability with the Health Assessment Questionnaire (HAQ), pain with a visual analogue scale (VAS), and disease activity by an active joint count and erythrocyte sedimentation rate (ESR). Questions concerning social support were also included. RESULTS: Emotional distress decreased slowly for a majority of the patients. The change reached statistical significance in the third year from study start. A minority (12%) showed continuously high and increasing levels of distress. Measures of disease activity were poor predictors of distress. The best predictor of distress over time was distress at baseline. Other predictors were gender, age, civil status, and social support. CONCLUSIONS: Emotional distress tended to decrease for most patients in this cohort, but a minority showed continuously high levels. Patients at higher risk of developing emotional distress over time had higher levels of distress at baseline, were younger, more often female, and cohabiting, and experienced less social support.

Adult↗