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Biomedical subjects

L P Chesterman

Publications and source records attributed to L P Chesterman.

2 recordsLinked to original sources

Multi-modal hallucinations.

A patient may experience hallucinations in more than one modality simultaneously or at different times and they may or may not appear to emanate from a single source. Current nomenclature is imprecise, often has particular diagnostic implications and fails to distinguish between these different phenomena. This has resulted in considerable confusion with a tendency to dismiss the importance of these symptoms. The various terms in current usage and the presence of these symptoms in a variety of different conditions are examined. To aid further research and improve clinical practice the authors advocate the use of the term multi-modal hallucinations and suggest operational criteria.

Auditory Perception

Treatment of narcolepsy with L-tyrosine: double-blind placebo-controlled trial.

A randomised, double-blind, placebo-controlled study of L-tyrosine was done in ten subjects with narcolepsy and cataplexy. Of twenty-eight visual analogue scales rating mood and arousal, the subjects' ratings in the tyrosine treatment (9 g daily) and placebo periods differed significantly for only three (less tired, less drowsy, more alert). Ratings of daytime drowsiness, cataplexy, sleep paralysis, night-time sleep, overall clinical response, and measurements of multiple sleep latency and tests of speed and attention did not differ significantly between tyrosine and placebo periods. Dietary supplementation with tyrosine 9 g daily for 4 weeks seems to have a mild stimulant action on the central nervous system but this effect is not clinically significant in the treatment of the narcoleptic syndrome.

Adult