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Biomedical subjects

L P Chong

Publications and source records attributed to L P Chong.

6 recordsLinked to original sources

Vitrectomy for perforating eye injuries from shotgun pellets.

Pars plana vitrectomy and scleral buckling were performed on 22 eyes of 19 patients for treatment of perforating eye injuries from shotgun pellets. We reviewed the intraoperative findings at the time of vitrectomy to determine what factors might influence final visual acuity. The presence of a total retinal detachment at vitrectomy portended a poor prognosis when compared with eyes without total retinal detachment, as only one of ten eyes with total retinal detachment obtained useful vision (P = .002). Preoperative separation of the posterior vitreous was associated with a favorable outcome when compared with the absence of posterior vitreous detachment (P = .035), as ten of 16 eyes with posterior vitreous detachment at the time of vitrectomy ultimately achieved functional vision. The locations of the exit wounds did not affect visual success in the overall series of patients. However, in the patients who achieved visual success, exit wounds outside the vascular arcades were more likely to be associated with final visual acuities of, or better than, 20/70 than were those within the arcades (P = .022). Other prognostic factors, such as the number of perforations and the use of cryotherapy, were also examined for their effects on final visual outcome. However, these factors did not appear to affect visual outcome statistically.

Adolescent

Ichthyoses and hyperkeratotic disorders.

Many of the ichthyotic disorders have characteristic ocular findings. These disorders include X-linked ichthyosis, lamellar ichthyosis, Sjögren-Larsson syndrome, KID syndrome, Refsum's disease, neutral lipid storage disease, chondrodysplasia punctata, and Richner-Hanhart syndrome. A knowledge of the ocular manifestations may provide a valuable aid to diagnosis in difficult cases. In some cases, knowledge of the ocular complications results in early referral for optimal ophthalmologic care.

Cataract

Pneumocystis carinii choroiditis after long-term aerosolized pentamidine therapy.

Pneumocystis carinii pneumonia is a major cause of morbidity and mortality in patients with the acquired immunodeficiency syndrome. When P. carinii is disseminated, the choroid may be involved and the infection is often fatal. We examined, treated, and followed up two patients who developed choroidal lesions typical of P. carinii while taking aerosolized pentamidine for prophylaxis. The choroidal lesions gradually resolved after three weeks of therapy with intravenous trimethoprim and sulfamethoxazole in one patient, and after three weeks of therapy with parenteral pentamidine in the other patient. The patients did not have clinical or laboratory evidence of P. carinii infection other than in the eye. It thus appears that early ophthalmologic examination may detect disease before it is threatening to sight and allow systemic therapy to be instituted before widely disseminated infection results in a fatal outcome.

Adult

Vitrectomy for advanced stages of retinopathy of prematurity.

We did a retrospective review of the consecutive vitrectomies for traction retinal detachment associated with retinopathy of prematurity performed at our institution. Fifty-eight eyes were operated on in 46 patients at less than 1 year of age, including 12 eyes with partial retinal detachments and 46 eyes with total retinal detachments. Only patients with at least six months follow-up were considered for success. Twenty-five eyes (43%) were anatomically reattached. Factors associated with good anatomic outcome included greater mean preoperative pupillary dilation, absence of posterior synechiae, deep anterior chamber, partial detachment or open-funnel total detachment configuration, and adequate posterior membrane removal. Of the 25 eyes with attached retinas, 11 had fixing and following visual acuities or better. Three eyes with attached retinas had no light perception and 11 eyes with attached retinas had light perception only. To maximize anatomic and functional results we emphasize the need to operate early, when the retinal funnel is still open.

Evaluation Studies as Topic