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Biomedical subjects

L P Hackett

Publications and source records attributed to L P Hackett.

72 records · Page 4Linked to original sources
PubMed1977

Determination of paracetamol in human serum.

A procedure is described that gives quantitative extraction of paracetamol from serum. This, together with derivatisation and gas chromatography, provides a simple method that facilitates the rapid estimation of the drug in serum in the range 5--500 mg/litre.

Acetaminophen↗
PubMed1977

Rapid identification of drugs in the overdosed patient.

A rapid analytical procedure is described for a variety of drugs that could be present in the overdosed patient. The technique used gives quantitative results for most of the drugs analyzed in serum using gas chromatography and incorporates thin-layer chromatography and spot tests for drug confirmation. The procedure is novel for it relies on the initial extraction of acidics, basics, and neutrals from serum acidified with hydroxhloric acid.

Chromatography, Gas↗
PubMed1977

Direct extraction procedure for the analysis of neutral drugs in tissue.

This paper describes an efficient extraction technique for the determination of neutral drugs in tissue. The extracts are clean and can be analyzed by gas liquid chromatography. The method gives good recoveries of most of the neutral drugs and the sensitivity is such that therapeutic levels can easily be detected.

Humans↗
PubMed1976

Rapid digestion and flameless atomic absorption spectroscopy of mercury in fish.

A rapid method is described for the determination of total mercury in fish samples. The sample is digested with nitric acid-sulfuric acid-potassium permanganate, and then reduced and aerated for measurement by flameless atomic absorption spectrophotometry. The average recoveries of organic and inorganic mercury added to fish were 93 and 95%, respectively. The uniformity of mercury levels in shark tissue has also been investigated.

Animals↗
PubMedDate not supplied

The analysis of several nonopiate narcotic analgesics and cocaine in serum using high-performance liquid chromatography.

This paper describes a procedure for the quantitative determination of methadone, meperidine, normeperidine, pentazocine, propoxyphene, norpropoxyphene, and dextromoramide in serum down to levels of 10 micrograms/L and of cocaine down to 25 micrograms/L. The procedure involves a simple extraction technique and high-performance liquid chromatography and is suitable for use in overdose drug screening, forensic toxicology, therapeutic drug monitoring, and pharmacokinetic studies.

Analgesics, Opioid↗
PubMedDate not supplied

Simultaneous determination of lidocaine, mexiletine, disopyramide, and quinidine in plasma by high performance liquid chromatography.

A high performance liquid chromatographic method is described for the simultaneous quantitation of four commonly prescribed antiarrhythmic drugs: lidocaine, mexiletine, disopyramide, and quinidine. An isocratic system using a reverse phase column was used to separate these compounds. Coefficients of variation were less than 4%.

Anti-Arrhythmia Agents↗
PubMedDate not supplied

Could activated charcoal be used to adsorb intraduodenal methyl tert-butyl ether spillage during its use in the dissolution of gallstones?

Methyl tert-butyl ether (MTBE) is becoming more frequently used in the non-surgical removal of cholesterol gallstones. However, during its introduction into the biliary tract, some spillage can occur and subsequent systemic absorption has been reported to lead to a variety of side effects. We have carried out in vitro experiments to assess the ability of activated charcoal to adsorb MTBE. A 10% aqueous suspension of activated charcoal was mixed with MTBE and its adsorption was estimated subsequently by gas chromatography. Adsorption varied from 38% at an activated charcoal: MTBE ratio of 1:1, to 96% at a ratio of 8:1. Only 3.2% of the adsorbed MTBE could be desorbed by resuspending the sedimented activated charcoal: MTBE complex in an equivalent volume of fresh distilled water. The results indicate that a single dose of activated charcoal (greater than 12 g) may be effective in minimizing systemic absorption of MTBE spilt during gallstone dissolution.

Adsorption↗