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Biomedical subjects

L P Istranov

Publications and source records attributed to L P Istranov.

At least 19 recordsLinked to original sources
PubMed2004

[Application hemostatic drug in capillary-parenchymatous bleeding].

Specific activity of a new hemostatic drug thrombocol was studied in experiments. Laboratory rabbits were used for management of experimental capillary-parenchymatous hemorrhage. The action of thrombocol was compared with hemostatic effect of other drugs: carbocol, combutek-2, super-4 (USA), collastipt (Germany), collagen sponge (Germany). It was found that thrombocol was highly hygroscopic, showed good adhesion to wounded surface, high plasticity and better hemostatic effect compared with other collagen-containing drugs.

Animals↗
PubMed2004

[Development and use of periodontal dressing of collagen and Lactobacillus casei 37 cell suspension in combined treatment of periodontal disease of inflammatory origin (a microbiological study)].

Periodontal dressing consisting of collagen and Lactobacillus casei 37 cell suspension (cell concentration 108 cells/ml) was created and used in combined treatment of patients with chronic generalized parodontitis. Efficacy of the developed isolation was explained by a considerable decrease of the number and frequency of isolation of aggressive microbial representatives (pigment synthesizing Bacteroids, Actinomyces and Str. intermedius) in periodontal pockets and also Fungus (Candida albicans). This periodontal dressing provided remission up to 10-12 months.

Chronic Disease↗
PubMed1999

[Method of protecting of sutures in the stomach and intestines].

The authors have developed and described the method for intraoperative prophylaxis of complications caused by incompetence of the sutures on the stomach and bowels. It consists in closure of the sutures along the line of contiguity by two-layers of compact-porous collagenous explants, which possess antibacterial properties, the period of resorption in abdominal cavity being 15-20 days. The characteristics of the explants are presented and their advantages compared to commonly used methods covering by pellicle or glue film peritonization by sero-muscular sutures. Application of collagenous explants from "Sanguicol" preparation in surgical treatment of 155 patients with external intestinal fistulas, compared to peritonization by sero-muscular sutures (66 patients), has demonstrated a high effectiveness of proposed explants in prevention of postoperative intraabdominal complications.

Acrylic Resins↗
PubMed1996

[The dynamics of bone defect healing after the implantation of collagen and hydroxyapatite complexes (an experimental morphological study)].

Healing of standard bone defects in the distal third of the femoral bone was studied in experiments on 48 rats. In order to repair the defect, colapol or a new composition with structurized collagen and hydroxyapatite powder and granulate KP-2 were used. Histological study showed that healing was optimal after repair with KP-2 composition: callus formed rapidly, as did the typical osseogranular complexes. Newly formed bone structures mature much sooner than after implantation of colapol. The authors come to a conclusion that the use of KP-2 composition holds good promise as material for maxillofacial surgery in plastic repair of bone defects.

Animals↗
PubMed1996

[Gapkol--a new osteoplastic material].

Hapcol, a new osteoplastic material, representing a biological composition on the basis of a natural biopolymer collagen with biologically compatible osteotropic mineral hydroxyapatite has been developed and allowed for clinical use. It is intended for use in dentistry in surgical treatment of periodontal diseases, deformations of the abutment tissues of the face, filling of bone defects after cystectomy, surgery for bone plasty, etc. Hapcol is characterized by antiinflammatory action, stimulates repair osteogenesis and collagenogenesis. Joint stock company Polistom starts commercial manufacture of the new material.

Animals↗
PubMed1991

[Experimental premises and 1st experiences in the clinical use of antibacterial vascular prostheses under circumstances of increased risk of suppuration].

It was shown on the basis of laboratory and experimental data that created antibacterial vascular prostheses are marked, on the main, by local bacteriostatic and anticoagulative effect. It was found that heparin concentration of 3 to 500 U per 1 kg collagen causes a hyperadhesive effect on blood platelets and facilitates the formation of the primary thrombocytic thrombus. The free surface energy grows in this case from 34 +/- 0.8 to 66.3 +/- erg/cm2. The optimal thromboresistant effect occurs in heparin content of 1 U per 1 mg collagen. That this choice is correct is confirmed on examination of the inner surface of the prostheses with an electron microscope after being in the blood flow for 45 minutes. Bifurcation and linear antibacterial prostheses were used in 9 patients with a high risk of suppuration verified by cultures of discharge from ulcers and lymph nodes, and the presence of lymphangitis and lymphadenitis. The effect was positive in 8 patients, 2 of them had superficial suppuration of the operative wounds.

Animals↗
PubMed1987

[Blood flow in skin wound tissue and systemic hemodynamics as affected by a collagen-dalargin complex].

In has been demonstrated that a collagen-dalargin complex increases blood flow in the granulation tissue (microsphere technique) due to the formation of new capillaries and a decrease in the vascular resistance. Dalargin had no effect on the capillary blood flow in the unaffected tissues. It has been concluded that the wound healing effect of dalargin may be related to its involvement in angiogenesis regulation.

Animals↗
PubMedDate not supplied

[Optical rotatory dispersion and circular dichroism of enzyme- and alkali-dissolved collagen].

Viscosity, dispersion of optical rotation and circular dichroism of collagen solutions was determined. Collagen solutions were obtained after treating collagen with enzymes--protorizine or prototerrizine, or with the mixture of 2,5 M NaOH--1 M Na2SO4 and acid-soluble collagen from calf skin. Molecules of "forcedly" solved collagen have an asymmetric shape with a conformation of a three-helical helix. After being heated the latter undergoes the transformation helix-coil similar to tropocollagen molecules.

Aspergillus↗
PubMedDate not supplied

[Fibril formation in solutions of solubilized collagen].

Influence of the preparations of bacterial proteinases, protorisine and prototerrisine, was studied on the stability of the mature collagen of beef skin. The chemical composition of the tissue has been shown to be changed by these enzymes inconsiderably. The tissue treated by orisine and terrisine is completely dissolved in 0.5 M acetic acid (solubilized collagen). When the solutions of such collagen are heated to 37 degrees within the pH range from 4 to 10 at the ionic strength of 0.25 fibrils are formed. Under electron microscope fibres are cross-striated that is typical of native collagen fibres with periodicity of about 640 A. After chilling to 4 degrees, a part of fibrils is dissolved again. Nephlometry was used to study the rate of fibril formation as a function of pH and temperature values. A conclusion has been drawn that the mature collagne dissolved after incubation with bacterial proteinases is close to the acid-soluble collagen fraction in the ability to produce fibres upon heating.

Binding Sites↗
PubMedDate not supplied

[Collagen plastic surgery in progressive myopia].

The technique of surgery is as follows: 4 implants of wetted and squeezed out collagen sponge, 7-8 x 20-22 mm in size, 2-2.5 mm thick, are introduced into Tenon's space to fill the gaps between the rectus muscles; a standard sterile hemostatic sponge or a colocyl sponge in employed. Experimental studies have shown the development of new episcleral connective tissue at the sites where the sponge has been introduced, the thickness of this tissue exceeding 1.5-2.5-fold that of the rabbit sclera. Altogether 200 eyes (100 patients) with myopia of 3.5-15 diopters have been operated on. Myopia progress has been stopped in 95% of cases; vision acuity has improved by 0.14-0.15 (p less than 0.001), clinical refraction has reduced by 0.9-1.0 diopters (p less than 0.001) in 84% of patients. A significant improvement of the hemodynamics has been achieved, as well as of the eye membrane rigidity (1.5-2-fold). The complications were only negligible diplopia early after surgery in 3 cases. Collagen plastic surgery is a simple method, marked for the availability of the implanted material; it is highly effective and in fact does not involve complications, this permitting its use in progressive myopia of more than 4.0-5.0 diopters.

Adolescent↗