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L P Maĭorova

Publications and source records attributed to L P Maĭorova.

14 recordsLinked to original sources
PubMed1987

[Effect of regulator cells induced by the influenza virus in adoptive transfer].

The protective effect of humoral and cellular immunity factors on experimental mouse influenza infection was studied in combination with a simultaneous analysis of the functional activity in the regulatory lymphocytes of donor mice. The efficacy of adoptive defense of recipient mice, that is the intensity of immune reactions in their organisms, was found to depend on the concrete functional state of donor mouse transferring cells. The exact time of activation of T-helper cells open certain prospects for the concrete pathogenetically grounded drug therapy.

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[Antitumor activity of cold-adapted strains of influenza virus in a model transformed murine tumor cells].

Influenza virus suppressed tumor growth after injection to tumor zone in a dose of 7-8 lg EID50, as was shown for two continuous mouse tumor cell strains, Ehrlich's carcinoma and L-1210 lymphoma. Influenza virus strains differed by their antitumor activity which correlated with their interferonogenic activity. Antitumor activity of influenza virus depended on the site of application, dose of the virus, and interferonogenic activity. Virus therapy of tumors stimulated specific cytotoxic activity towards tumor antigens.

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PubMedDate not supplied

[Experimental coronavirus encephalomyelitis in mice].

A combined comparative virological, morphological, and immunological study of experimental coronavirus encephalomyelitis was carried out in mice in order to elucidate the pathogenetic mechanisms involved in the formation of the foci of lesions in acute and chronic forms of the disease. Intracerebral inoculation of C3H mice with the neurotropic JHM strain of murine hepatitis virus induces a disease with demyelinization foci in the CNS running acute, subacute, or chronic course. This model underlies a concept that demyelinating diseases are caused by viruses producing immunopathologic responses realized via certain histocompatibility loci. The long-term persistence of viral antigen in the CNS and liver may be explained by virus replication in hepatocytes and oligodendrocytes at low levels, and exacerbations of the disease are prevented by the immune system.

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PubMedDate not supplied

[Protective effectiveness of the blood sera and immune system cells from mice immunized with live or inactivated influenza virus].

The results of the study of comparative protective role of humoral and cell-mediated immunity factors obtained from inbred donor mice immunized with live or inactivated influenza virus are presented. The superiority of the live virus over the inactivated preparation as the inducer of not only humoral but especially cell-mediated immune response was demonstrated by the effectiveness of passive intranasal protection of the infected mice, by the degree of inhibition of virus reproduction in the lungs of the protected mice, and by the capacity for interferon production by the cells of the immune system of donor mice.

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PubMedDate not supplied

[Effectiveness of humoral and cellular protective factors in experimental influenza].

The results of application of a new experimental approach proposed by A. A. Smorodintsev in investigations of a comparative defensive role of cellular and humoral factors of influenza immunity in the phenomena of recovery are presented. A more marked effect on the processes of recovery of cellular defence factors in infected mice than those of the sera of the same animal donors was observed. The effectiveness of the action of the cellular factors of immunity on the development of experimental influenza infection depended on the duration of the viral process to a lesser extent than the effect of homologous antibodies. The protective activity of lymphocytes and macrophages of inflammatory exudates was particularly high when the cells obtained early after immunization (4-5 days) were used.

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