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Biomedical subjects

L P Maiorova

Publications and source records attributed to L P Maiorova.

4 recordsLinked to original sources
PubMed1982

Comparison of the anti-influenza activities of antibodies and immune system cells administered intranasally to syngeneic mice.

A novel experimental approach was employed to investigate the protective role of cellular and humoral factors in antiviral immunity under conditions of their prophylactic administration into the tracheobronchial cavities of normal mice-recipients which were challenged 24 hr later with influenza virus A/PR/8/34 (H0N1). The highest protective effect was afforded by intranasal administration of immune serum (91.3%) as compared with splenocytes (65.2%). The addition of immune serum to cell suspensions or pooled lymphocyte and macrophage fractions previously isolated from the spleen increased the protective effect of these materials by 97--100% thus surpassing the protective effect of immune serum alone. The protective effect of passively administered cells from inflammatory exudates of peritoneal or tracheobronchial cavities was higher than that of a more concentrated splenocyte suspension; the results were comparable only if the number of splenocytes was 4- to 5-fold that of the exudate cells. The degree of the protective effect was strictly proportional to the concentration of immune system cells administered to the concentration of immune system cells administered to the syngeneic recipients.

Administration, Intranasal↗
PubMed1982

[Demyelinization process in acute and subacute experimental encephalomyelitis].

The authors present the results of studying encephalomyelitis caused by the neurotropic (IHM) strain of the murine hepatitis virus in 60 mice of the C3H line infected intracerebrally at the age of 4 weeks. Morphological examinations of the brain carried out on the 5th-13th day (the acute period) and the 14th-30th day (the subacute stage) have shown that it is myelin-producing cells that are affected first in this form of encephalomyelitis, while the periaxonal process observed is a consequence of this affection. Proofs of this conclusion are presented. It is shown that in subacute encephalomyelitis, similar processes develop. Degeneration and infection of oligodendrocytes are not so pronounced in that case, as in the acute disease. However, destruction of even individual oligodendrocytes may lead (due to the peculiarities of their structure and function) to an avalanche-like process of demyelinization. It is supposed that the vesicular degeneration of myelin may arise in the sites of close contact between the myelin membranes and the cells of inflammation infiltrates (release of lysosomal enzymes and toxic products formed in edema). In the latter case the viruses serve as an antigen depot that causes and maintains the inflammatory process.

Acute Disease↗