PubMed Health⌕ Search

Biomedical subjects

L P Pavlova

Publications and source records attributed to L P Pavlova.

At least 19 recordsLinked to original sources
PubMed2004

[Comparative evaluation of therapeutic effects of 3 and 4 antitubercular agents at the initial stage of the treatment of renal tuberculosis].

Three groups of the parameters of the therapeutic effects of 3 and 4 antituberculous drugs on renal tuberculous inflammation were identified. The primary effect of 4 drugs was much frequently manifested itself by the normalization of urinalysis and the transfer of cultured to uncultured Mycobacterium tuberculosis (MBT). The equivalent effect of 3 and 4 drugs was characterized by the similar rate of continuation of specific mycobacteriuria, by the detection of MBT in the cavernous contents from the removed tuberculosis-afflicted kidney and by the equivalent morphological characteristics of tuberculous inflammation involution. The negative impact of the therapeutic action of 4-component chemotherapy appeared as a much larger number of cases of intolerance of antituberculous drugs, hepatic and renal failures, and toxic-and-allergic reactions.

Antitubercular Agents↗
PubMed2000

[Raising of the treatment efficacy of renal colic and prophylaxis of acute calculous pyelonephritis in patient with ureterolithiasis].

In 116 patients with renal colic, caused by stones of ureters, conservative treatment with application of hyperbaric oxygenation (HBO) was conducted. Under the influence of oxygenotherapy during 3 days obstruction of the urinary tracts in all patients had disappeared as well as acute urostasis, clinic symptoms of the renal colic, progress of an acute infectious-inflammatory process stopped, complications were eliminated. Echo-positive subjects had disappeared from kidneys, in one patient renal calculus had dissolved, in 5--calculi had reduced in size and fragmentated, in 9--had not changed. In 108 patients the ureters had freed from calculi, in 8--calculi had reduced in size and migrated in distal direction.

Acute Disease↗
PubMed1999

[Urogenital tuberculosis in the Ukraine population].

The prevalence and incidence rates of urogenital tuberculosis in the Ukraine in the past 10 years were studied. They tended to decrease in the first period (1988-1992) and to become stable in the second period (1993-1997), being equal to 10.71 and 1.0 per 100,000. In the past 5 years, the incidence of urogenital tuberculosis tended to increase among urban residents as compared to rural ones. These changes show a total trend in the population living in the radioactively polluted area.

Air Pollution, Radioactive↗
PubMed1991

[An experimental study of the safety of a chemical monovalent tableted cholera vaccine in enteral administration].

The safety of experimental chemical cholera monovalent vaccine in tablets, produced by the institute "Microbe" (Saratov, USSR), has been studied. The study has shown that the vaccine, administered to adult rabbits and germ-free suckling rabbits by the enteral route, retains residual toxicity, mainly due to the presence of O-antigen. One or two administrations of 1-2 human doses of this preparation to adult rabbits induce minimal structural changes admissible from the viewpoint of safety. After immunization made in two administrations immunobiological transformation develops more rapidly and is more pronounced than after immunization in a single administration.

Administration, Oral↗
PubMed1990

[The effect of different Yersinia pestis antigens on the cellular link in immunity].

Immunization with live plague vaccine has been shown to give no protection to thymectomized mice from subcutaneous challenge with Y. pestis virulent strain. Under the action of the vaccine or individual Y. pestis antigens (fraction I) the functional and morphological activation of thymocytes and macrophages is observed, more pronounced in C57BL/6 mice and less pronounced in CBA mice. Y. pestis antigenic preparations (fractions I and II, pesticin) act as T-cell mitogens and are thus capable of inducing the in vitro proliferation of thymocytes. At the same time the in vivo action of fraction II induces a decrease in the level of lymphocytes in the peripheral blood of mice and the destruction of lymphocytes in their thymus and spleen.

Animals↗
PubMed1988

[Morphological study of the damaging effect of an EB vaccine strain of the plague microbe in inbred mice].

The data obtained during the study of the morphological changes in the internal organs and blood of 6 mouse strains at the early stages of anti-plague immunity are presented. It has been established that the introduction of 5.10(3) and 1.10(5) m. b. of the EV vaccine strain resulted in the development of morphological changes typical of residual virulence. The degree of these changes depended on the haplotype of the animals and the dose used. The most resistant to injury induced by EV strain were CBA mice (haplotype H-2k) and the most sensitive were C57BL/6 mice (haplotype H-2b).

Adrenal Glands↗
PubMed1986

[Effect of intestinal microflora on the pathogenesis of cholera intoxication].

Germ-free minipigs, previously treated with bacteroids, develop cholinergic reaction after the intragastric administration of Vibrio cholerae exotoxin. The intensity of this reaction, disturbances in homeostasis, and the character of morphological changes depend on the dose of choleragen, the bacteroid strain, and the presence of the concomitant (Escherichia coli) and residual microflora in the intestine.

Animals↗