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Biomedical subjects

L Pacifico

Publications and source records attributed to L Pacifico.

At least 55 records · Page 3Linked to original sources
PubMed1987

Yersinia enterocolitica infection in pregnant mice and their offspring.

In order to investigate the susceptibility to Yersinia enterocolitica infection before and during pregnancy, and the potential vertical transmission to the offspring, female adult mice were intravenously inoculated with 3 x 10(4) CFU of Y enterocolitica either 7 days before conception or on day 8 of pregnancy. Infection was assessed by determining the number of bacterial counts in spleen of mothers, entire body of fetuses, placentas, and spleen of newborns. Mice challenged 7 days before pregnancy had cured at the time of mating. Pregnancy did not reactivate infection. In contrast, mice challenged at day 8 of pregnancy showed an intense reactivation of the splenic infection from day 15 of pregnancy to delivery. Moreover, they gave birth to live offspring, that were or were not infected, and to stillborn pups that were heavily infected. Splenic infection of mothers and living offspring that had been congenitally infected, cured by 8 days after delivery.

Animals↗
PubMed1986

Efficacy of computer-assisted management of respiratory failure in neonates.

We modified an algorithm for mechanical ventilation of infants with respiratory distress syndrome to create an interactive user-friendly computer program. To determine the effectiveness of this computer program, we evaluated the correction of deranged arterial blood gases in three groups of neonates: group I, treated before the introduction of the computer into the nursery; group II, managed by pediatric residents with the guidance of the computer program; group III, treated after the introduction of the computer into the nursery but managed without consideration of the computer output. Arterial blood gas values improved more frequently in the neonates managed with computer consultation (group II, 65/75, 87%) than in both control groups (group I, 37/57, 65%, P less than .005; and group III, 46/63, 73%, P less than .05). Furthermore, increases in ventilatory support in the presence of normal arterial blood gas values occurred only in patients managed without computer guidance. In a teaching institution, more effective care of neonates with respiratory failure may be facilitated by computer-assisted management of mechanical ventilators.

Blood Gas Analysis↗
PubMed1985

Clostridium difficile isolation in leukemic children on maintenance cancer chemotherapy. A preliminary study.

Between December 1982 and November 1983, stool specimens from 15 children with acute lymphoblastic leukemia, who were on maintenance cancer chemotherapy, were examined weekly for the presence of Clostridium difficile and its toxin. Four out of 15 patients were positive for C. difficile: three patients had stool specimens that did not contain toxin, but cultures yielded growth of toxigenic C. difficile on only one occasion. The fourth patient, who had a recent history of hospitalization, particularly aggressive cancer chemotherapy, neutropenia, and antibiotic therapy, excreted both C. difficile and its toxin for at least 1 month. All children were asymptomatic at the time of positive cultures. This preliminary study reveals a low rate of C. difficile colonization in leukemic children on maintenance cancer chemotherapy.

Adolescent↗
PubMed1980

[Renal transplantation in Bologna].

From october '76 to march '79 at the Clinica Chirurgica I of the University of Bologna 50 renal graft have been performed with living donor in 8 cases and with cadaver donor in 42. In the living donor group there was one death for rejection and sepsis. The remaining 7 patients are all alive with normal renal function. Among the 42 patients with cadaver donor 6 died: 3 early (one for gastric hemorrage, one for necrosis of the ascending colon, and one for rejection) and 3 late (two following many rejection episodes and one for miocardial infarction). 6 more patients underwent transplantectomy (4 for acute and 2 for chronic rejection). The 27 remaining patients have normal renal function. The only early important surgical problem was one urinary fistula in the 15th postoperative day successfully reoperated. The major late surgical complication was a renal artery stenosis distal from the arterial anastomosis followed by difficult but effective surgical correction. The authors regret not having been able to use more than half of the possible cadaver donors for refusal of the relatives.

Cadaver↗
PubMed1980

[Clinico-statistical analysis of the problem of the cadaver donor in renal transplantation (clinical experience from 1945 to the present time)].

The series of cadaver donors in Bologna hospitals from 1975 to today is reviewed. All possible donors were compared with those actually utilized and the reasons that led to renunciation in a large percentage of cases are analysed. The examination shows that among the factors limiting the number of donors utilized particularly important were the criteria adopted for establishment of donor suitability, family consent and the results of support therapy of the donor's vital functions.

Adolescent↗
PubMed1980

[Althesin in the treatment of status epilepticus].

In view of its anticonvulsant effects in the experimental animal, its low toxicity, and its manageability, Althesin was used at doses of 80-600 mg in the treatment of barbiturate and benzodiazepine resistant epilepsy in 11 patients aged 15 months to 62 yr. Lasting suspension of the disease was obtained in 8 subjects. Burst suppression was achieved in 7 of these cases with 80-120 drops/min of a 10% solution of Althesin in 10% laevulose. No side-effects were observed.

Adolescent↗
PubMed1979

The use of althesin in drug-resistent status epilepticus.

The properties of Althesin (anticonvulsant activity, depression of oxygen consumption, lowering of ICP, rapid excretion) led us to use this steroid combination to treat 11 patients in status epilepticus resistant to the standard drugs (benzodiazepines and barbiturates). The administration of Althesin by slow intravenous injection was ineffective in 2 of the 3 patients thus treated. The doses used (2--10 ml) were probably too small. One only administration of a 10% solution of Althesin in 10% fructose by intravenous drip (the rate was calculated so as to obtain the burst suppression stage at the EEG) stopped status epilepticus in 7 of the 9 patients thus treated. In this group the doses used varied from 25 to 50 ml. The 2 patients in whom it was necessary to repeat Althesin administration and combine it with other drugs had both been operated on for severe brain injuries involving marked cerebral edema. In spite of the very small number of cases, the definitive arrest of status epilepticus obtained in 8 out of 11 patients first treated with other drugs is encouraging: Althesin probably may be regarded as an adjunct in the treatment of status epilepticus.

Adolescent↗