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L Pajor

Publications and source records attributed to L Pajor.

At least 91 records · Page 5Linked to original sources
PubMed1986

Microsomal desaturation of stearic acid in relation to lymphocyte activation.

The conversion of stearic acid to oleic acid (delta 9-desaturase) was followed in mouse thymocytes stimulated by either concanavalin A or concanavalin A + interleukin-2 resulting in different rates of cell proliferation. To estimate the plasma membrane turnover of oleic acid as compared to that of a saturated fatty acid, double-label experiments ([14C]oleic acid, [3H]palmitic acid) were performed. Following an inhibition delta 9-desaturase was found to be activated from the fourth hour of stimulation. In the early period of cell activation this process proved to be independent of protein synthesis, whereas in the stage of proliferation it was dependent on it. Increased membrane fluidity in the first 30 min of activation is not likely due to enrichment of oleic acid. Cell proliferation and microsomal desaturation seem to be coupled and an increasing amount of oleic acid is at least one of the factors resulting in increased fluidity of the surface membrane of proliferating cells.

Animals↗
PubMed1986

Ultrastructural, lectin histochemical and immunohistological observations on Merkel cell tumors.

The clinicopathological and ultrastructural findings of 10 cases of Merkel cell tumor (MCT) are presented. Three patients died rapidly due to tumor dissemination. The tumor cells in eight out of the 10 cases were positive for neuron-specific enolase, however, all were negative for the ten polypeptide hormones examined, as well as for the argentaffin and argyrophil reactions. One of the patients had suffered from chronic lymphocytic leukaemia. Particularly in this case, but also in the others, the differentiation of MCT from a malignant lymphoma necessitated immuno-histological, lectin histochemical and ultrastructural studies. The focal peanut agglutinin positivity of the tumor cells in 6 out of the 10 MCTs seems to be a characteristic feature of these cells.

Aged↗
PubMed1986

Functional morphology of the adrenal cortex in newborns. I. Morphometric study.

Adrenal cortex of fetuses from abortion and newborns as well as 3 anencephalic monsters between 16 and 40 weeks gestational age was investigated. In order to follow the activity of adrenal cortex the volumes of nuclei and of cells were determined by means of morphometry in both the fetal and the definitive zones. The volume of cells showed correlation with gestational age only in the definitive zone. The absence of significant changes in the other (fetal) zone raises the possibility that dysfunction of the adrenal cortex and the consecutive insufficient adaptation could be made responsible for premature birth and perinatal mortality in the cases reported here.

Adrenal Cortex↗
PubMed1986

Functional morphology of the adrenal cortex in newborns. II. Morphological and biochemical analysis of lipid accumulation.

The adrenal cortex of 32 newborns and of 3 anencephalic monsters of 16 to 40 weeks' gestational age was examined. Functional activity of the adrenal cortex was followed by analysis of the zonal distribution of lipids and by measurement of the total cholesterol content. The cholesterol content ranged between 0.15 and 0.85 mg/100 g. Cholesterol accumulation was highest in the anencephalic monsters. The relative cholesterol content failed to show any correlation with gestational age. When compared with the biochemical determination of cholesterol content, morphological investigation of lipid accumulation proved to be superior and to be a suitable method for estimation of zonal maturity even in individual cases.

Adrenal Cortex↗
PubMed1984

Primary cardiovascular amyloidosis with benign monoclonal gammopathy.

A 54-year-old woman is reported whose primary amyloidosis was diagnosed at autopsy. Amyloid deposits were found in the myocardium, the striated muscles, the smooth muscle layers of the gut and the wall of the blood vessels. The deposits showed resistance to induced proteolysis. A large number of mature plasma cells was demonstrated in the bone marrow, and immunocytochemical studies revealed a considerable increase in the proportion of plasma cells which were positive for kappa light chains of immunoglobulins, indicating a monoclonal gammopathy. This view was strongly supported by the unexpected finding that amyloid deposits were positive for kappa light chains. The relationship between the kappa positive reaction of amyloid and its resistance to induced proteolysis are discussed.

Amyloid↗
PubMed1981

Ultrasonic measurement of residual urine: a method requiring no catheter.

Residual urine was measured with the two-dimensional and the gray-scale equipments (Kretz-Technik) in 26 cases each. The results were checked by catheterization. The difference between the ultrasonographic and the catheter values was 20 to 40 ml for the two-dimensional, but only 5 to 10 ml for the gray-scale apparatus. Ultrasonography is regarded as a reliable and entirely harmless procedure, suited for the measurement of residual urine.

Aged↗
PubMed1980

[The value of rectal examination in the diagnosis of prostatic cancer (author's transl)].

Rectal examination is the basic step in the diagnosis of carcinoma of the prostate. However its accuracy is limited because cancerous nodules are often difficult to differentiate from certain benign conditions which cause areas of induration. Needle biopsy is necessary for establishing the diagnosis of cancer. 699 men with palpable lesions of the prostate underwent transperineal biopsy. Out of 251 patients with advanced lesions only 171 (68.1%) had a histologically proved carcinoma of the prostate. Out of 119 men with an isolate firm nodule 50 (42%) had a positive biopsy whereas in only 62 (18.8%) of 267 biopsies of glands with changes in consistency and indurations histological examination confirmed the diagnosis of prostatic carcinoma.

Humans↗
PubMedDate not supplied

Autonomic nervous system dysfunction involving the gastrointestinal and the urinary tracts in primary Sjögren's syndrome.

OBJECTIVE: Antibodies reacting with the m3 subtype muscarinic acetylcholine receptor appear to be an important pathogenic factor in primary Sjögren's syndrome (pSS). As this receptor subtype is functionally important in the gastrointestinal and urinary tracts, and very little is known about the autonomic nervous system function in these organs in pSS patients, the occurrence and clinical significance of an autonomic nervous system dysfunction involving the gastrointestinal and urinary tracts were investigated. METHODS: Data on clinical symptoms attributable to an autonomic dysfunction were collected from 51 pSS patients. Gastric emptying scintigraphy and urodynamic studies were performed on 30 and 16 patients, respectively, and the results were correlated with patient characteristics and with the presence of autonomic nervous system symptoms. RESULTS: Gastric emptying was abnormally slow in 21 of the 30 examined patients (70%). Urodynamic findings, compatible with a decreased detrusor muscle tone or contractility were found in 9 of the 16 patients tested (56%). Various symptoms of an autonomic nervous system dysfunction were reported by 2-16% of the patients. CONCLUSION: Signs of an autonomic nervous system dysfunction involving the gastrointestinal and the urinary systems can be observed in the majority of pSS patients. This high occurrence is rarely associated with clinically significant symptoms. The authors presume a role of autoantibodies reacting with the m3 muscarinic acetylcholine receptor in the elicitation of the autonomic dysfunction.

Adult↗