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L Palombini

Publications and source records attributed to L Palombini.

At least 55 records · Page 3Linked to original sources
PubMed1992

Fine-needle aspiration biopsies of breast masses. An additional experience with 1153 cases (1985 to 1988) and a meta-analysis.

A series of 1153 fine-needle aspiration biopsies (FNAB) of breast masses obtained during the period 1985 to 1988 in one institution was examined. The following diagnostic accuracy values were found: sensitivity, 93.0%; specificity, 92.4%; predictive positive value, 93.7%; and efficiency, 92.8%. These results were compared with a previously published series for the period 1976 to 1984. The diagnostic accuracy values did not differ significantly between the two series.

Biopsy, Needle↗
PubMed1992

Nucleolar organizer regions in aggressive and nonaggressive basal cell carcinoma of the skin.

Nucleolar organizer regions (NOR) were investigated on routine paraffin-embedded histologic sections of 11 aggressive basal cell carcinomas that recurred and/or metastasized (BCC2) and 11 nonaggressive basal cell carcinomas (BCC1). The absolute number of NOR per nucleus was higher in BCC2 than in BCC1, and their distribution pattern was also different. In fact, the means of argyrophilic staining of NOR (AgNOR) counts in the two groups of tumors by two observers were 6.56 with a SD of 1.98 for the nonaggressive and 9.48 with a SD of 2.12 for the aggressive basal cell carcinomas. A statistical analysis of these data using the Student's t test confirmed these observations (t = 64.49). Problems in the evaluation of NOR and possible comparison with other experiences are also discussed. The authors conclude that a quantitative assay of AgNOR and perhaps their distribution pattern may provide information useful to recognize BCC2 and hence may be of help in their prognostic prediction.

Adult↗
PubMed1990

Primary laryngeal malignant fibrous histiocytoma: a case report.

Malignant fibrous histiocytoma (MFH) of the upper respiratory tract is rare. We report a case of laryngeal MFH in a 78-year-old man. The patient died 8 months after the first surgical treatment. The clinicopathologic features are described, and the importance of electron microscopy and immunohistochemical techniques in the differential diagnosis with so-called "sarcomatoid carcinoma" is stressed. The tumor has an aggressive biological behavior and tends to recur and metastasize.

Aged↗
PubMed1990

Comparative morphometric analysis of aggressive and ordinary basal cell carcinoma of the skin.

A morphometric analysis was performed on histologic sections of 11 cases of aggressive basal cell carcinoma that recurred and/or metastasized after the first diagnosis (BCC2) and on 11 ordinary basal cell carcinomas (BCC1). The considered parameters were as follows: nuclear area, perimeter, maximum diameter, feret x, feret y, form perimeter, and form area. The results show numeric differences between the two groups for the first five parameters. A statistical analysis was performed between BCC1 and BCC2 for all the considered parameters using a two-sided t test for independent samples. The test showed significant differences between the first five parameters except for the two form factors. A multivariate analysis was performed using area and perimeter values of the compared groups that amplified the discrimination threshold between the two groups. The authors conclude that a morphometric assessment may bring significant contribution in the knowledge and in the outcome prediction of basal cell carcinoma.

Aged↗
PubMed1990

Fine needle aspiration cytology of medullary thyroid carcinoma: a review of 18 cases.

A series of 18 consecutive medullary thyroid carcinomas (MTC) diagnosed by fine needle aspiration cytology (FNAC) is described. The most important diagnostic cytologic criteria were the dispersed cell pattern, the polygonal appearance of the cells, binucleated cells and the presence of amyloid. Other less common cytologic features are reported and the variable microscopic appearance of MTC is pointed out. The possibility that this cytologic variability of MTC may be by itself an important diagnostic feature is proposed.

Adolescent↗
PubMed1989

Hodgkin's disease mimicking suppurative lymphadenitis: a possible pitfall in fine-needle aspiration biopsy cytology.

We report one case of nodular sclerosing Hodgkin's disease with uncommon pseudosuppurative presentations in fine-needle aspiration biopsy (FNAB) samples and on histopathologic material. The criteria for cytologic diagnosis include atypical mononuclear cells and diagnostic SR cells in the purulent exudate. This lesion is considered a possible pitfall in FNAB cytology of Hodgkin's disease.

Adult↗
PubMed1989

A morphometric approach to the grading of chondroid tumours on fine-needle smears.

A morphometric study was performed on 600 nuclei from 6 benign chondroid tumours (BCL) (3 enchondromas and 3 exostoses), 600 nuclei from 6 well-differentiated chondrosarcomas (WDC) and 200 nuclei from moderately-differentiated chondrosarcomas (MDC) obtained by fine needle aspiration biopsy. The parameters considered were nuclear area, perimeter and maximum diameter. Moving across the three groups of lesions the nuclei appeared progressively larger. A statistical analysis was performed on the three groups. Significant differences between the means of all the parameters considered were observed. The authors suggest that morphometric analysis may be a possible step in the cytologic diagnosis and grading of chondroid tumours.

Adult↗
PubMed1988

Fine-needle aspiration biopsies of breast masses. A critical analysis of 1956 cases in 8 years (1976-1984).

A series of 1956 fine-needle aspiration biopsies (FNAB) of breast masses is described. The diagnostic accuracy of this series (sensitivity, 95.7%; specificity, 89.6%; predictive value of positivity, 95.9%; and efficiency, 94.0%) was compared with that published in the literature. Statistically significant differences were found between the level of diagnostic accuracy in series published by pathologists who diagnosed smears prepared by clinicians and surgeons (Group A), and those published by pathologists who performed palpation and aspiration, and made the cytologic diagnosis by themselves (Group B). These differences mainly consisted of a lower number of false-positives and "unsatisfactory" samples in Group B series.

Biopsy, Needle↗
PubMed1988

The role of morphometry in the cytology of well-differentiated hepatocarcinoma and cirrhosis with atypia.

A morphometric study was performed on 200 nuclei per case in six well-differentiated hepatocarcinomas and in six cirrhoses with cytologic atypia, using samples obtained by fine needle aspiration (FNA) biopsy of the liver. The parameters measured were the nuclear area, the nuclear perimeter and the maximum nuclear diameter. The nuclei of well-differentiated hepatocarcinomas could be distinguished from those of cirrhoses on the basis of the larger size and greater anisonucleosis of the former. A statistical analysis (using a two-sided t-test) of the means of the parameters showed significant differences between the two diagnostic groups. These results suggest that morphometric analysis can help in the differential diagnosis between well-differentiated hepatocellular carcinoma and cirrhosis with cytologic atypia in FNA biopsy samples.

Adult↗
PubMed1986

Thyroid localization in adult histiocytosis X.

Authors report on a rare case of thyroid involvement by histiocytosis X. A 27-yr-old man with diabetes insipidus and lung bullous disease of 2 yr duration was found to have thyroid gland infiltration by differentiated histiocytosis X. This was based on cytological findings consistent with the diagnosis, obtained by fine needle aspiration biopsy. Endocrine studies revealed altered hypothalamic-pituitary function accounted for by a hypothalamic lesion.

Adult↗
PubMed1986

Malignancy-associated cellular markers (MAC) in oral and bronchial epithelial cells in sputum specimens: possible morphologic marker for high-risk groups (asbestos-exposed workers).

To verify a possible role of malignancy-associated cellular markers (MAC) in high-risk groups, the authors reviewed a total of 291 consecutive sputum specimens from 97 workers exposed to asbestos. The asbestos workers were matched according to smoking habits and cellular changes. Twelve subjects (12.3%) had MAC in epithelial cells; eight were smokers, four nonsmokers. Among MAC+ smokers, three sputum specimens contained cells of squamous metaplasia and one had cells from carcinoma in situ. Two MAC+ nonsmokers had cells of squamous metaplasia, too. In addition, MAC+ cells were also identified in four inflammatory samples, belonging either to smokers or nonsmokers. Two MAC+ subjects had a negative sputum specimen. In keeping with these results, the authors believe that MAC evaluation in sputum specimens might be of help in the oncologic follow-up of asbestos-exposed workers.

Air Pollutants, Occupational↗
PubMed1985

Breast carcinoma metastasized in ovarian thecoma (a case report).

We describe a patient with breast cancer metastatic to ovarian thecoma. This finding, to the best of our knowledge, has yet to be reported in literature regardless of the fact that there are many gynecological neoplastic associations. Our hypothesis is that this unusual finding is not accidental, but rather benign lesions may be natural resting sites for metastatic disease. An autopsy series is required to elucidate this incidence.

Adult↗
PubMed1984

Mucoid carcinoma of the breast on fine-needle aspiration biopsy sample: cytology and ultrastructure.

16 cases of mucoid carcinoma of the breast were diagnosed in specimens obtained by fine-needle aspiration biopsy. The subsequent tissue examination confirmed the cytologic diagnosis in all 16 cases but revealed in 1 case an association with an endocrine component and in 3 cases the presence of an invasive ductal component. The diagnostic and prognostic necessity of distinguishing pure forms of mucoid carcinoma from those associated with invasive ductal carcinoma or endocrine differentiation means that investigations other than fine-needle aspiration biopsy are also required. In every case, the cytologic diagnosis of mucoid carcinoma should be considered as an aspect of the tumor and not representative of the entire neoplasm.

Adenocarcinoma, Mucinous↗