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L Parra

Publications and source records attributed to L Parra.

24 records · Page 2Linked to original sources
PubMed1989

Studies on the mechanism of action of the antihypertensive agent cicletanine.

DOCA-salt rats have been previously shown to respond readily to the antihypertensive agent cicletanine (C). To study the mechanism of action of this drug, DOCA-salt rats were subchronically (14 d) treated with a 30 mg/kg (p.o.) dose of C and, once killed, their thoracic aortas challenged with a concentration (0.1 microM) of the vasocontractile agent noradrenaline (NA). Arteries from rats treated with C responded less to NA than the arteries from rats given placebo for the same time period. In another set of experiments, prior treatment with the inhibitor of prostaglandin synthesis indomethacin (2 x 2.5 mg/kg, s.c.) blunted the acute antihypertensive effect of C (30 mg/kg, p.o.) in this experimental model. These data suggest that C may work through a long-term induced blockade of the sympathetic tone that could be somehow related to a promotion of the formation of the vasodilator prostaglandin prostacyclin.

Animals↗
PubMedDate not supplied

[Subcapsular hematoma after ESWL].

Contribution of 2 cases of post-ESWL subcapsular haematoma in patients with HBP. One of them underwent surgical drainage. In the second case a more conservative attitude was followed. Review of related literature.

Aged↗
PubMedDate not supplied

[Complications of rigid ureteroscopy].

UNLABELLED: Peri- and post-operative complications higher than 37c (15%) encountered in 250 urethroscopies performed between May 1985 and January 1989 are presented in this paper. These experiences are compared to those from other 20 series (2,599 urethroscopies) representing 14.5% complications. In order to study their pathogeny, the sample was divided into four groups: CONTROL GROUP: 27 patients where normality of urinary tract was demonstrated in 92.6% of all evaluations made at intervals of about 20 months. Technical scope: Two groups chronologically different: 16% complications in urethroscopies performed in 1985 and 7% complications in those performed in 1986. Differences in the techniques applied: classic extraction (14%) vs. urethroscopy (13%) and electrohydraulic lithotrity (42%) vs ultrasonic lithotrity (12%). Finally, a description is made of those cause believed to be responsible for major complications: perforation, avulsion and ureteral stenosis.

Endoscopes↗
PubMedDate not supplied

The antihypertensive agent cicletanine reverses vascular hyperreactivity to noradrenaline and cardiac hypertrophy in DOCA-salt rats.

Cicletanine, when given p.o. either acutely or subchronically, was found to produce a clear-cut antihypertensive effect in the deoxycorticosterone salt experimental rat model. This compound was able to reverse high blood pressure, even at doses deprived of diuretic effect. Subchronic treatment (30 mg/kg, p.o.; 14 days) with cicletanine reduced the enhanced contractile response to noradrenaline in deoxycorticosterone salt rat aortic strips and reversed the cardiac hypertrophy in these animals. The antihypertensive effect after long-term treatment with cicletanine in deoxycorticosterone salt rats appears to be related to an antagonism of the elevated sympathetic drive to the vascular smooth muscle.

Adrenalectomy↗