Biomedical subjects

L Pawłowski

Publications and source records attributed to L Pawłowski.

3 recordsLinked to original sources

PubMed1979

Effect of p-chlorophenylalanine on avoidance learning of two differentially housed mouse strains.

The effect of p-chlorophenylalanine (PCPA) has been studied on the acquisition of avoidance learning and on brain concentrations of 5-hydroxytryptamine, 5-hydroxyindoleacetic acid and tryptophan of differentially housed male mice of Albino Swiss and DBA strains. The results obtained do not support the hypothesis that learning ability varies inversely with the concentration of brain 5-hydroxytryptamine. PCPA can appear as influencing learning ability of different strains of mice differentially housed, depending more on the emotional baseline of the animals than on brain 5-hydroxytryptamine modification.

5-Hydroxytryptophan↗

PubMedDate not supplied

The effect of antihistamine drugs on the neuroleptic-induced catalepsy.

The effect of atropine on the spiperone- or reserpine-induced catalepsy was compared with the effect pure antihistamines (chlorcyclizine, diphenhydramine, mepyramine) and antiserotonin -- antihistamine drugs (cyproheptadine, danitracen). All the drugs were used in equipotent doses in respect of their central cholinolytic action, assassed previously on the basis of the tremorine test. The potency of the antiserotonin action of chlorcyclizine, diphenhydramine and mepyramine was estimated by assessing the ID50 values of these compounds in the test based on antagonism to L-5-hydroxytryptophan action in the mouse. The spiperone-induced catelepsy, was most effectively inhibited by classical histaminolytics and less by drugs of a combined antiserotonin and antihistamine action. For the reserpine-induced catalepsy, differences in action of the two groups of drugs were less distinct. In both cases atropine produced the weakest anticataleptic effect. Amodiaquine, an inhibitor of histamine degradation, enhanced the catalepsy induced by either neuroleptic (the reserpine-induced catalepsy in a statistically significant menner). A possibility that the anticataleptic action of chlorcyclizine, cyproheptadine, diphenhydramine, mepyrymine and danitracen depends on the blockade of the histamine receptors in the brain is discussed.

5-Hydroxytryptophan↗

PubMedDate not supplied

An evidence for the central serotoninergic activity of viloxazine.

The effects of viloxazine on the flexor reflex of the hind limb of the spinal rat and the blood pressure in the pithed rat were studied. Viloxazine (1--16 mg/kg) stimulated the hind limb flexor reflex in the dose-dependent manner. This effect of viloxazine was inhibited by serotonin receptor blockers, cyproheptadine, danitracen and metergoline, and by serotonin uptake blocking agents imipramine and clomipramine. H22/54, an inhibitor of serotonin synthesis, was much less active in this respect. Desipramine, a noradrenaline uptake inhibitor, had no effect on the stimulatory action of viloxazine. Viloxazine (similarly as serotonin) elevated blood pressure in the pithed rat. This action of viloxazine was abolished by cyproheptadine but potentiated by pargyline, an inhibitor of MAO. It is suggested that viloxazine may facilitate the serotonergic transmission in the central nervous system.

Animals↗