Biomedical subjects
Publications and source records attributed to L Peliti.
We consider a population of fixed size and reproducing asexually, evolving in a rugged fitness landscape. Selection takes place only via the elimination of individuals with unfit genomes. Unfit genotypes are distributed at random in genotypic space. The genetic structure of the population and the speed of genetic drift are explicitly computed in the infinite genome limit.
We introduce a simple model describing the evolution of a population of information-carrying macromolecules. We discuss the asymptotic dependence of the variability of the population on different parameters, representing the severity or the fluctuations of the environment. We show the existence of a transition separating a neutralist evolutionary regime from a trapped one. We investigate the dependence of the evolutionary behavior of the population on the correlation properties of the fitness landscape.
We introduce a simple model of molecular evolution, with a fixed population and a rugged fitness function. We exhibit the analogy between the crossover from a neutralist to an adaptative evolutionary behavior and the percolation transition in genome space.