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L Peng

Publications and source records attributed to L Peng.

148 records · Page 9Linked to original sources
PubMed1985

[Comparative ultrastructure of the normal mucosa and the adenocarcinoma cells of the human large intestine].

This paper presents the comparative observation by transmission electron microscopy (TEM) of ten cases of adenocarcinoma of the large intestine and the normal colon mucosa. The ultrastructural features of the carcinoma cells were as follows: The basement membrane was perforated by cytoplasmic projections of the carcinoma cells, extending into the lamina propria. The membrane of the neighbouring cells was quite smooth, the interdigitation appeared sparse and the intercellular space was often dilated. The phenomenon of desmosome separation was found. Therefore, careful observation of the changes in the cell membrane is helpful in the diagnosis of colonic adenocarcinoma.

Adenocarcinoma↗
PubMedDate not supplied

Ultrastructural study of neurons in metachromatic leukodystrophy.

Neuronal inclusions were investigated with the electron microscope in several regions of the central nervous system (CNS) of a patient with late infantile metachromatic leukodystrophy (MLD). The neuronal perikarya of the spinal anterior horn cells and the neurons in the globus pallidus were distended with concentrically arranged lamellar inclusions which closely resembled membranous cytoplasmic bodies (MCB) of gangliosidoses. Large pyramidal neurons in the motor cortex also contained a few smaller MCB-like inclusions. These neuronal inclusions were relatively uniform in size and in morphology in contrast to pleomorphic inclusions in glial cells in MLD. Membrane-bound vacuoles containing moderately electron-dense granular materials or electron-dense aggregates were found in some pyramidal neurons in the Ammon's horn and cerebellar Purkinje cells. These changes were interpreted to represent the reaction of these neurons to subtle cellular injury which may or may not be related to metabolic derrangement in MLD.

Central Nervous System↗