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Biomedical subjects

L Perrone

Publications and source records attributed to L Perrone.

At least 73 records · Page 4Linked to original sources
PubMed1984

Circannual rhythms of plasma growth hormone, thyrotropin and thyroid hormones in prepuberty.

To clarify the occurrence of circannual GH, TSH, T4 and T3 rhythms in prepuberty we have been studying, for a four year period, 150 healthy subjects, aged 6-10, by cross-sectional design. Plasma samples were taken at 0800 h and all hormones were measured by RIA. The occurrence of any circannual rhythm was statistically investigated by the cosinor method. A significant rhythm was validated (P = 0.02) only in TSH secretion, with annual crest time in December; GH, T4, T3 did not show a circannual rhythm. Our results seem to strengthen the hypothesis that the thyroid hormones, at least before puberty, do not play an important role in the regulation of circannual TSH periodicity.

Child↗
PubMed1984

Zinc levels of serum, hair and urine in homozygous beta-thalassemic subjects under hypertransfusional treatment.

The concentration of zinc in serum, hair and urine has been examined in 92 homozygous beta-thalassemic and 81 control subjects. The results were not statistically different in the subjects of each group studied (thalassemic and control persons of different ages: 1-12, 12-18, and 18-35 years). In the thalassemic children no statistically significant differences were observed between those normally growing and those with impaired growth. The authors hypothesize that hypertransfusional treatment prevents zinc deficiency in the thalassemic patients.

Adolescent↗
PubMed1983

Circannual rhythms of plasma luteinizing hormone, follicle-stimulating hormone, testosterone, prolactin and cortisol in prepuberty.

For a period of four years we have been studying 106 healthy males and 66 healthy females, aged 6-10, by cross-sectional design, to look for evidence of a circannual rhythm in LH, FSH, testosterone, PRL, and cortisol secretion. Plasma samples were taken at 0800 h and all hormones were measured by RIA. A cosine function was fitted to the single data to indicate any significant circannual (about 1 year) rhythm and to estimate its parameters: mesor, amplitude, and acrophase. Annual changes were validated in the secretion of: LH (annual crest time in January in both sexes), testosterone (studied only in males, annual crest time in July), and PRL (significant rhythm only in females with annual crest time in March). FSH and cortisol did not show an annual rhythm in both sexes. Our data suggest that sex influences the circannual hormonal rhythms from prepuberty onwards.

Activity Cycles↗
PubMed1983

Sexual precocity in a boy due to hypersecretion of LH and prolactin by a pituitary adenoma.

The paper reports on precocious puberty and galactorrhoea in a 4 8/12 year old boy. Roentgenograms of the skull showed slight lateral bulging of sella floor and pneumoencephalography indicated a pituitary adenoma with a suprasellar extension. Pre-operative study of anterior pituitary function was normal except for increased values of LH (900 mIU/ml), testosterone (2000 ng/ml) and prolactin (215 ng/ml). After removal of a chromophobe pituitary adenoma by transfrontal surgery the galactorrhoea disappeared within 10 days. Post-operative endocrine evaluation showed immediate normalization of LH, testosterone and prolactin values.

Adenoma↗