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Biomedical subjects

L Perrot

Publications and source records attributed to L Perrot.

31 records · Page 2Linked to original sources
PubMedDate not supplied

[Laparoscopic treatment of acute cholecystitis. Incidence of anatomo-clinical variations (271 cases)].

The study is based on 1050 laparoscopic cholecystectomies for gallstones performed between 1991-1999, out of which 271 were preoperatively considered as acute cholecystitis (25.8%). The clinical, biological and ultrasound criteria were rigorously respected. The preoperative period of 1 to 5 days (mean--2.5) was used for re-equilibration and antibiotic and antithrombotic therapy. The intraoperative criteria were clinical, echolaparoscopical, cholangiographical and bacteriological and established in 219 cases the diagnostic of acute cholecystitis. The final diagnostic, on histopathological basis, confirmed the preoperative diagnosis of acute cholecystitis in 224 cases. The microscopical reexamination in the remainding controversy cases reclassified other 18 as acute cholecystitis (final concordance ratio--242:271). The preoperative overvaluation may be consecutive to a too rapid (before the constitution of specific lesions) or too delayed intervention (the aspect becoming chronical). The elements of diagnostic discordance are raising the problem of case selection and the necessity for standard classification of histological lesions in acute cholecystitis.

Adult↗
PubMedDate not supplied

[Multiple effects of resorcinol on thyroid function (author's transl)].

In rats, I.V. injected resorcinol led to a decrease in thyroid radioiodine uptake and labelled iodothyronine/iodotyrosine ratio with no changes in the percent of thyroidal labelled iodide or radioiodine release. When thyroid lobes were incubated in vitro with radioiodine, resorcinol concentrations from 10(-3)M to 10(-6)M gave an increase in the percent of thyroidal labelled iodide and iodotyrosine/iodothyronine ratio. In animals fed 5% resorcinol for 2 weeks we observed an increase in thyroid weight, a decrease in plasma T4, no change in the percent of free T4, a decrease in T4 half life and no significant changes in T3 half life. Thyroidal labelled MIT/DIT and T3/T4 atios increased. Resorcinol, given in diet during 5 days to rats which had a low thyroidal thyroglobulin content after PTU administration for 2 weeks, gave, in comparison with rats fed PTU only, an increase in thyroidal thyroglobulin/DNA ratio and a decrease in thyroidal radioiodine release contrasting with an increase in plasma TSH. These differences did not exist when resorcinol was given for one month.

Administration, Oral↗
PubMedDate not supplied

[Thyroid hormones and the metabolism of lipoproteins].

Variations, generally not very marked, observed in triglycerides levels during thyroid affections are the result of the action of thyroid hormones on very low density lipoprotein (VLDL) metabolism. Hepatic synthesis of VLDL is increased in hyperparathyroidism due to elevation of circulating fatty acids levels, and in hypothyroidism only in obese patients. Catabolism of VLDL is accelerated in hyperthyroidism and slowed in hypothyroidism. The variations are probably related to changes in activity of lipoprotein lipase and/or hepatic triglyceride lipase, as well as structural modifications in VLDL. Variations in cholesterolemia observed during thyroid affections result mainly from alterations in low density lipoprotein (LDL) metabolism, parallel variations occurring in apoprotein B levels. Thyroid hormones increase cholesterol synthesis, and accelerate LDL catabolism by increasing the number of apoprotein B receptor in peripheral tissues and probably by other mechanisms independent of these receptors. Significant variations in cholesterol levels carried by high density lipoproteins (HDL) are not observed during hypothyroidism, an inconstant reduction being noted in hyperthyroidism. Apoprotein A2 levels are unchanged in thyroid disorders, those of apoproteins A1 being reduced in hyperthyroidism and normal in hypothyroidism, though they diminish transiently during substitutive treatment of the latter condition.

Animals↗
PubMedDate not supplied

[Effect of thyroid function on ketogenesis (author's transl)].

Thyroid hormone effects have been studied in both rats and human. In rats ketone body levels are increased by thyroid hormone excess at the initial phase of starvation. Glucose levels are also increased at the initial and late phase of starvation. Ketone bodies production of isolated liver cells from thyroidectomized fed rats (14 +/- 0,2 muMol/g/h) are decreased when compared with cells from thyroidectomized fed rats treated with triiodothyronine 63 +/- 3 muMol/g/h). These changes are related to a direct effect of T3. Ketone bodies levels are increased in Grave's diseases. The increase is significantly correlated to thyroid hormone levels.

Animals↗