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Biomedical subjects

L Picciotto

Publications and source records attributed to L Picciotto.

At least 37 records · Page 2Linked to original sources
PubMed1985

Hepatitis B immunisation with a reduced number of doses in newborn babies and children.

74 healthy babies born to mothers positive for hepatitis B surface antigen (HBsAg) were randomly divided at birth to receive either HB immunoglobulin and 2 doses of HB vaccine 2 months apart, or HB immunoglobulin and 3 doses of HB vaccine 1 month apart. 80 healthy babies born to HBsAg, anti-HBs, and anti-HB core (c) negative mothers were randomly divided at birth to receive either 2 doses of vaccine 2 months apart or 3 doses 1 month apart. The seroconversion rates and the geometric means of anti-HBs titres were lower in both groups of babies given 2 doses of vaccine than in the groups given 3 doses. 60 pairs of children at risk, aged 1 to 12 years and HBsAg, anti-HBs, and anti-HBc negative, were randomly divided to receive either the 2-dose regimen or the 3-dose regimen. The seroconversion rates and the geometric means of anti-HBs titres were satisfactory in both groups.

Child↗
PubMed1983

Presence of delta antigen in liver biopsies of HBsAg positive patients with chronic liver diseases living in the Naples area.

In a study of the presence of delta-Ag in liver biopsies of HBsAg positive patients with chronic liver diseases living in the Naples area, delta-Ag has been found only in patients with HBsAg positive chronic active hepatitis and in none of HBsAg positive patients with other liver diseases including those with chronic persistent hepatitis. The data obtained support the hypothesis that the simultaneous infection with HBV and delta-agent, and superinfection with delta-agent in HBsAg positive patients predispose the outcome of chronic hepatitis.

Biopsy↗
PubMed1981

[Aspecificity of the immunodiffusion reaction for the diagnosis of non-A non-B viral hepatitis].

A precipitating antigen-antibody system was detected by immunodiffusion using acute and convalescent sera from patients with non-A, non-B (NANB) viral hepatitis in which the diagnosis was made by exclusion. The system showed identity with reference sera. Positivity for antigen was found in 5 out 13 patients with acute NANB hepatitis, but also in 3 out 8 patients with acute A hepatitis, in 6 out of 15 with acute B hepatitis and in 95 out of 221 voluntary blood donors. Antibody was detected in all the above mentioned categories of patients and also in normal subjects in percentages ranging from 9.1 to 25.0 percent. The lack of specificity observed is in contrast with results of other reported serological NANB related systems.

False Positive Reactions↗
PubMed1980

[Greater concentration of anti-hepatitis B antibodies (anti-HBs) in specific hyperimmune human gamma globulins (non-anti-hepatitis B) as compared with normal human gamma globulins].

Twenty-seven lots of standard immunoglobulin from 5 different producers and 18 lots of specific immunoglobulin (non anti-Hepatitis B) were titrated by RIA test for anti-HBs content. The highest titre in lots of standard IG (1:40) was lower than the lowest titre of the lots of specific IG (non anti-Hepatitis B) (1:44). The difference between means (1:17 and 1:42) was statistically significant (p less then 0,01). The reasons for the difference are discussed.

Antibodies, Viral↗
PubMed1976

[Homologous and heterologous antibody response induced in man by anti-influenza vaccine containing A/England/42/72 and b/Massachusetts/71].

In november 1973, 43 subjects living in a home for aged were given one dose of influenza vaccine, containing A/England/42/72 and B/Massachusetts/71. After 4 and 20 weeks, sera were tested for antibody contentto the homologous and to A/port Chalmers/1/73 viruses by haemoagglutination inhibition technique. Control group included 23 untreated subjects. The satisfactory increase in the anti-A/England/42/72 antibodies induced by vaccine indicated a good antigenic potency of the A component. The satisfactory cross-reacting response suggests that the "drift" in antigenic content between A England/42/72 and A/Port Chalmers/1/73 was moderate. On the contrary the increase in anti-B/Massachusetts/71 antibodies after vaccination was observed only in a limited number of cases. Twelve subjects (9 treated and 3 controls) experienced upper respiratory tract infections which appeared to be not related to infuenza viruses.

Aged↗