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Biomedical subjects

L Pierangeli

Publications and source records attributed to L Pierangeli.

At least 19 recordsLinked to original sources
PubMed1998

Cardiac rhabdomyosarcoma: a clinicopathologic and electron microscopy study.

A 66-year-old woman was admitted to the hospital with a neurological syndrome characterized by ataxia and diplopia. Magnetic resonance of the brain documented an ischemic medullary lesion. Examination of the heart revealed a grade 2/6 systolic murmur at the left sternal border and apex that radiated towards the axilla. The echocardiography study showed a mild mitral regurgitation, and an abnormally enlarged posterior papillary muscle was found in the left ventricle. Two weeks after admission, the patient died suddenly due to a stroke. At autopsy, a recent vast swollen ischemic cerebral infraction was found. Furthermore, two old infarcts were observed in the spleen. A cardiac examination showed a white-gray ulcered mass in the left ventricle and histological analysis revealed a rhabdomyosarcoma.

Aged↗
PubMed1996

Blood pressure response to exercise in young subjects with and without parental history of hypertension.

We examined 150 young male adults in the Italian Air Force to evaluate the correlation between blood pressure (BP) response to bicycle exercise and early structural changes of the left ventricle and the carotid arteries. The subjects were divided into three subgroups: (1) borderline hypertensives; (2) normotensives having one or both parents with hypertension; (3) normotensives without family history of hypertension. All subjects underwent a submaximal exercise test, echocardiography and carotid ultrasonographic study. The echocardiographic examination showed no significant difference between the three subgroups, while the vascular ultrasonographic examination showed a significant difference in carotid thickness between borderline hypertensives and the two other groups. The exercise test induced an abnormal hypertensive response only in the borderline group. We also considered the variation of systolic BP between maximum stress and the 1st, 3rd, 5th and 8th minute of recovery phase. From our data it seems that more than the exercise test, recovery BP values may be suggestive of an exaggerated cardiovascular response.

Adult↗
PubMed1992

Limitations of the electrocardiographic diagnosis of left ventricular hypertrophy: the influence of left anterior hemiblock and right bundle branch block.

We analysed the performance of the electrocardiogram in diagnosing left ventricular hypertrophy in 70 patients with isolated left anterior hemiblock and in 75 patients with right bundle branch block, either isolated (44 cases) or associated (31 cases) with left anterior hemiblock. Left ventricular hypertrophy defined as an echocardiographically determined left ventricular mass greater than 261 g in men and 172 g in women or left ventricular mass index greater than 125 g/m2 in men and 112 g/m2 in women was present in 48 subjects (57%) with isolated left anterior hemiblock and 33 subjects (44%) with right bundle branch block. In patients with isolated left anterior hemiblock the best results were obtained using the SV1 or SV2 + (RV6 + SV6) greater than 25 mm with 74% in sensitivity and 67% in specificity; the criterion SIII + (R + S) maximal in a precordial lead greater than or equal to 30 mm showed a sensitivity of 74% but a specificity of 47%. In the whole group of patients with right bundle branch block none of the criteria nor combination of criteria achieved an acceptable performance (sensitivities ranged from 17% to 41% and specificities ranged from 54% to 85%). When these patients were divided according to the presence or absence of concomitant left anterior hemiblock the electrocardiographic indexes mostly showed, in comparison to whole group, higher values in sensitivity and lower values in specificity in right bundle branch block plus left anterior hemiblock and an opposite behaviour in isolated right bundle branch block.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1989

[Effects of acute loading of alcohol on platelet aggregation in normal subjects].

Ten healthy subjects were submitted to alcohol loading (0.8 g/kg body weight; average alcohol blood level 0.97 g 0/00). The number of platelets, hematocrit and ADP-induced platelet aggregation curves did not show any variation from baseline. Significant changes (p less than 0.05) were observed as regards latent period (increased) and maximum amplitude (reduced) for collagen-induced platelet aggregation. In agreement with others, the authors conclude that alcohol definitely inhibits platelet aggregation.

Adult↗
PubMed1981

[Contribution of M-mode echocardiography and myocardial scintigraphy for study of ECG pattern of left ventricular hypertrophy with giant negative T waves (author's transl)].

Eight normotensive patients with electrocardiographic criteria for left ventricular hypertrophy with giant negative T waves were studied with Thallium-201 imaging and M-mode echocardiography. In all the patients Thallium scanning demonstrated increased thickness of the left ventricular walls. In five of the above cases areas of increased uptake were noted in the apical region which had increased thickness as compared to the rest of the left ventricular wall. Echocardiography showed in one subject obstructive hypertrophic myocardiopathy and in another two asymmetric septal hypertrophy. In the remaining patients there was always present septal and posterior wall hypertrophy. Reliable echocardiograms of the apex were done in five subjects and in these hypertrophy was noted. The results of the two techniques were compared and correlated clinically and with the literature. The authors conclude in agreement with other studies that the picture of electrocardiographic left ventricular hypertrophy with giant negative T waves is indicative of hypertrophic myocardiopathies. Specifically, for us, the apical hypertrophy may be the only feature of the myocardiopathy or be part of a generalized left ventricular hypertrophy which is usually asymmetric septal hypertrophy.

Adult↗
PubMed1980

[The genetic influence on the labile pseudo-ischemic T-wave (author's transl)].

After the demonstrated familial incidence of the "labile pseudo-ischemic T-wave" patterns, a research has been carried on in order to ascertain the possible genetic conditioning of the anomaly. The analysis of the pattern of the families, formed starting from the subjects carrier of the above-mentioned pattern, carried on with the Haldane sibships method corrected with that proposed by Lejeune, leads to affirm that the models of hereditary transmission able of explaining the found out distributions are of a not simple recessive type. The distribution of frequence of the subjects by "aplotype HLA" does not permit to settle a reliable correlation between the considerated electrocardiographic anomaly and the aplotype, at least as far as the number of the examined cases is concerned.

Adult↗
PubMed1978

[A specific anomalies of ventricular repolarization. Dysgenetic syndromes caused by functional asymmetry of the cardiac sympathetic nerves].

The following is a personal study of the case histories of 3 patients, spontaneous carriers of "labile pseudo-ischemic T wave" and of their direct consanguineous, a total of 25 subjects. In these three families the family incidence on electrocardiographic anomalies is confirmed. In these same subjects as well as in others belonging to families examined in a previous study, a total of 90 subjects, the duration of the QT interval was measured, showing values which tended to be above the average and, in some cases, above the accepted maximum. The analogy among the anomalies of the ventricular repolarization to be found during the course of neurological diseases and under experimental conditions of unilateral lesions of the sympathetic cardiac innervation and the "labile T wave" syndrome, sometimes coexisting in the same family with a report of elongated QT interval, suggests the hypothesis that this may be placed within the ambit of disgenetic syndromes from alterations of the functional balance between right and left component of the sympathetic heart innervation.

Adult↗