Method for measuring suture tension in surgery.
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Electronics, Medical↗
Biomedical subjects
L Pirola
Publications and source records attributed to L Pirola.
Trace elements analysis in biological samples by proton nuclear activation.
A method for the multielemental analysis of trace elements in biological samples by medium energy proton nuclear activation (PNA) has been developed. The response linearity, reproducibility and reliability of the method have been tested by a set of preliminary measurements. Results concerning the quantitative determination of the concentrations of Sr, Cu, Fe, Zn and Se in human serum are presented. Activation was induced with a 23 MeV proton beam from the AVF cyclotron of the University of Milan, by means of (p, 2n) reactions on the nuclei of the elements under study. The quantitative determination was obtained by an internal reference method and by comparison with a standard sample of serum doped with known quantities of the elements of interest. A clinical investigation of the zinc content of serum in children has been performed.
Activation Analysis↗
Ferrokinetic studies with stable isotopes as tracers.
A methodology for ferrokinetic studies based on the administration of iron stable isotopes was developed. Fractional plasma clearance and intestinal iron absorption in rabbits were determined using the double tracer technique. Three rabbits were given 58Fe solution intravenously and about 40 min later 57Fe solution orally. Blood samples were drawn at different times following administration. The analysis of the single iron isotopes content in plasma samples was made by proton nuclear activation. The results were compared with those obtained from the administration, to the same rabbits, of the radioactive isotopes 55Fe and 59Fe. The agreement was found to be satisfactory.
Animals↗
An iron metabolism study in humans by means of stable tracers.
An investigation of iron metabolism in a female patient volunteer by administration of stable iron isotopes as tracers was performed. The applied methodology had already been tested in rabbits in comparison with radioactive tracer technique. The subject under study was given 58Fe solution intravenously and about 45 min later 57Fe solution orally. Ten blood samples were drawn at different times within 522 min from injection. Single iron isotopes content in plasma samples was determined by proton nuclear activation. A Compton suppressor system was utilized to improve the detector limits. The characteristic parameters of iron plasma clearance and of iron intestinal absorption were determined.
Activation Analysis↗
Molybdenum metabolism studied by means of stable tracers.
An investigation on molybdenum metabolism by administration of molybdenum stable isotopes was performed. Fractional intestinal absorption was determined in animals by the double tracer technique. The investigated subjects were given an enriched solution of Mo-96 orally and, a few minutes later, an enriched solution of Mo-95 intravenously. Blood samples were drawn at different times following the tracer administration. The Mo-95 and Mo-96 contents in plasma samples were determined by proton nuclear activation. The described methodology offers a means for the study of molybdenum metabolism in humans without radiation risk.
Administration, Oral↗