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Biomedical subjects

L Quadracci

Publications and source records attributed to L Quadracci.

4 recordsLinked to original sources

Experience with antilymphocyte globulin in 144 renal transplant recipients.

In patients receiving cadaveric kidneys and treated with antilymphocyte globulin (ALG) the one-year graft survival 59%. The corresponding figures with living related donors were 87% and 83%, respectively. Side effects of ALG, of which allergic reactions were the most common, prompted its withdrawal in 33% of the cases. All patients studied developed antibodies against horse gammaglobulin when tested with a passive haemagglutination inhibition technique. ALG seems to act upon the T-cells since the number of cells forming rosettes with sheep red blood cells was reduced.

Antilymphocyte Serum↗

Lymphocyte subpopulations in uremics and in transplanted patients.

In 30 chronically uremics, 37 renal transplanted patients and 31 controls, the number of T- and B-cells was calculated as well as the lymphocyte response to the mitogens PHA, Con A and anti-B2m. In uremics the relative number of T-cells was normal, the number of B-cells was reduced and the response to mitogens was suppressed. During the early post transplantation period the relative number of both T- and B-cells was reduced as well as the mitogenic response. Following three months of successful transplantation the relative counts of T-cells and the response to mitogens returned to normal. The relative number of B-cells remained lowered however.

B-Lymphocytes↗