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Biomedical subjects

L R Davis

Publications and source records attributed to L R Davis.

25 records · Page 2Linked to original sources
PubMed1976

Changing blood picture in sickle-cell anaemia from shortly after birth to adolescence.

The blood picture of children with sickle-cell anaemia was found to change with age. The changes were most marked in the first year but the mean level of haemoglobin, haemoglobin F, and target cells fell until adolescence, and irreversibly sickled cells rose. Reticulocytes, Howell Jolly bodies, and normablasts altered little after one year. The fall in haemoglobin F suggested a delayed changeover from fetal to adult haemoglobin production. It was concluded that the blood changes in sickle-cell anaemia were progressive throughout childhood.

Adolescent↗
PubMed1975

Failure of laboratory and radiological studies to predict jejunal mucosal atrophy.

Of 58 children with suspected malabsorption, 27 were shown to have subtotal or partial atrophy, and 31 had normal mucosal histology. Oral glucose tolerance tests, faecal fat excretion, D-xylose excretion tests, Prosparol absorption studies, haematological investigations, and radiological examination of the small bowel failed to distinguish these two groups and frequently gave misleading results. It is concluded that in suspected coeliac disease small intestinal biopsy should be performed as a primary investigation.

Age Determination by Skeleton↗
PubMed1972

Target cells in haemoglobinopathies.

A semi-quantitative method of estimating the number of target cells in blood films has been developed. It has been applied to 250 films from normal persons, pregnant women, and patients with a variety of haemoglobinopathies. Allowing for the frequency of target cells found in normal films the results show that such an examination is of value in eliminating or suggesting certain haemoglobinopathies, but not in excluding the majority of the traits.

Anemia, Sickle Cell↗
PubMedDate not supplied

Normal blood cell values in the early mid-trimester fetus.

Samples of pure fetal blood from 116 fetuses of 15-21 weeks' gestation were obtained by direct vision fetoscopy. Ninety nine of these fetuses, presumed to be haematologically normal, were suitable for analysis. The data obtained show that the erythropoietic system is evolving rapidly in this gestational age range. The myeloid series shows no significant increase or decrease in numbers apart from eosinophils and basophils which increase significantly with gestational age whereas the platelet count remains constant. The growing application of fetoscopic blood sampling to the prenatal diagnosis and management of fetal blood disorders renders mandatory a knowledge of normal fetal blood values.

Erythrocyte Count↗