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L R DeGaeta

Publications and source records attributed to L R DeGaeta.

2 recordsLinked to original sources

Abdominal trauma.

Abdominal injuries are an important cause of morbidity and mortality. In the face of more obvious traumatic lesions, life-threatening intra-abdominal injuries may be initially overlooked. Plain abdominal and chest radiographs may prove diagnostic for specific injuries. However, normal or equivocal studies should not exclude the diagnosis of significant abdominal trauma. In patients who are clinically stable in whom there is suspicion of abdominal injury, additional imaging procedures should be undertaken for more definitive evaluation. At this time, computed tomography is the examination of choice for the assessment of the liver, spleen, and kidneys. In all cases, direct consultation with the radiologist should lead to the most expeditious plan for evaluation of the traumatized patient.

Abdominal Injuries↗

Liposomes loaded with contrast material for image enhancement in computed tomography. Work in progress.

Large unilamellar phospholipid vesicles were prepared and loaded with various radiographic contrast media. Body CT following in vivo administration of these vesicles in the rat demonstrated opacification of organs associated with the reticuloendothelial system. Image enhancement in the spleen and liver was dose dependent and was linearly related within the dose range investigated. Contrast enhancement was observed within five minutes of intravenous administration, was maximal 60 minutes after injection, and declined during the second hour. Clearance of the radiographic contrast material was complete within 24 hours. Diffuse splenic lymphoma following intraperitoneal or intrasplenic injection of lymphoma cells, and solitary lymphoma nodules following intrahepatic injection were readily detected as nonenhanced areas following injection of liposomes.

Animals↗