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L R Fan

Publications and source records attributed to L R Fan.

2 recordsLinked to original sources
PubMed1997

[Regulation of traditional Chinese medicine formulae bailong on cAMP-PKA and DAG-PKC signal pathways of human gastric cancer cells].

OBJECTIVE: To evaluate the effects of traditional Chinese medicine formulae (Bailong) on cAMP/PKA and diacylaglycerol (DAG) protein kinase (PKC) pathways of the MGc80-3 cells. METHODS: cAMP level, DAG content and activities of PKA and PKC were measured in different groups: (1) control, (2) 1.8 mg/ml Bailong, (3) 1.8 mg/ml Bailong +20 ug/ml PKA inhibitor, (4) 5 mumol/L PKC inhibitor. RESULTS: When MGc80-3 cells were in treatment with Bailong for 3 hours, cAMP level and PKA activity were 11.27%, and 19.7% higher than that of the control, while DAG content and PKC activity were 47.0% and 64.2% lower than that of the control; When PKC pathway was blocked by PKC inhibitor GF-109203X, cAMP level and PKA activity were increased by 78.8% and 33.5% as against that of the control, while the DAG content and PKC activity were decreased by 40. 3% and 56.3% respectively. When MGc80-3cells were treated with Bailong, and at the same time, blocked PKA pathways by PKA inhibitor, cAMP level and PKA activity were decreased by 46.0% and 28.9%, on the other hand, DAG content and PKC activity were increased by 50.7% and 51.6% as against that of the Bailong group. CONCLUSIONS: (1) There was relationship of causes and result between differentiation of MGc80-3 cells and the signal pathways. (2) Results of this study were similar to that of hexamethylenebisacetamide (HMBA). It is shown that the two signal systems are the foundation of regulative effects of Chinese medicine formulae Bailong or HMBA on proliferation and differentiation in MGc80-3 cells.

Adenocarcinoma, Mucinous↗
PubMed1996

[Job strain and drinking behavior].

The aim of this survey study was to explore the influence of work on individual's drinking behavior. From October 1994 to March 1995, the present researchers implemented a self-administered questionnaire survey on workers in the manufacturing sector in Metropolitan Kaohsiung area, southern Taiwan. Of the 1,117 subjects selected, 668 (61.8%) stated that they had had one or more drinks during the preceding month. The average daily consumption of alcohol was 0.2 +/- 0.9 drinks (with a range of 0 to 12 drinks and a median of 0.02 drinks). In addition, 188 (28.8%) of the subjects reported having experienced drinking-related problems during the preceding month, and 35 respondents (5.2%) gave escape from job stress as the reason for their drinking in the preceding month. The result of multivariate analyses showed that workers who reported less autonomy in their job were more likely to experience drinking-related problems (odds ratio [OR] = 1.3) and to drinking for psychological relief (OR = 1.2); that workers who reported more demanding job conditions were more likely to drink for escape (OR = 2.5) but had lower levels of drinking (t = -2.5, p = 0.01); and that workers who reported high levels of job strain were more likely to experience drinking-related problems and to drink for relief but had lower levels of drinking. The details and implications of this result will be discussed.

Adolescent↗