Strongyloides stercoralis hyperinfection and the acquired immunodeficiency syndrome.
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Biomedical subjects
Publications and source records attributed to L R Grillo.
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This paper describes 2 cases of tricuspid valvular dysplasia (TVD) associated with aortic stenosis and mitral incompetence in newborns. Mitral regurgitation was due to dysplasia, which resembles its tricuspid counterpart and should be termed 'mitral valve dysplasia'. This association of tricuspid and mitral valve dysplasia has been reported only once before. The concomitance of mitral and tricuspid incompetence is noteworthy, since mitral regurgitation can produce left heart failure and mask tricuspid valve disease.
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A new phase of breast conserving surgery has started very recently, aimed at eliminating axillary dissection in node-negative patients by using the sentinel lymph node (SN) technique. Between November 1998 and January 2000 we performed 151 operations for breast cancer on 145 patients. We performed axillary lymphoscintigraphy using 99Tc-labeled human serum albumin microcolloidal particles injected subdermally in 50 patients who met our selection criteria. In this series we focused on the success rate of scintigraphic and surgical sentinel node identification. The number of scintigraphic identifications of the SN was 44 (88%). Only forty-three cases were evaluable, as in one case mapping showed an internal mammary hot node. All SNs were located at the first level. After removal of the SN complete axillary dissection was performed. Eighteen patients (41.8%) had metastatic disease in the axilla. There were five (11.6%) false negatives: two in T2 tumors, one in a T4 tumor and two in T1c tumors. We consider this series as our training series. Our results are similar to those reported in the literature. We believe that the most reasonable approach to SN biopsy is a two-step procedure: the ideal candidates are patients with T1 cancer who can undergo the operation in an outpatient setting under local anesthesia and sedation. Complete axillary dissection is performed only if paraffin sections and immunohistochemistry show metastatic disease.
The authors describe a case of multiple myeloma that developed several extraskeletal localizations. They evaluated the relation between the onset of the testicular tumor and the following myeloma characteristics: tumor burden, clinical phase, response to therapy and prognostic significance. The patient presented a rapid and dramatic clinical evolution of the disease with extensive spread also to the soft tissues of the abdominal wall. Chemotherapy did not achieve any effect and the patient died due to progression of the myeloma.
A case of polyarticular pigmented villonodular synovitis associated with many congenital phenotypic peculiarities (such as shortness, blue sclerae, flattened nose, low-set ears, hypertelorism, curly hair and pulmonary stenosis) is described. The presence of many of the typical signs of the Noonan syndrome and the histological finding of giant cells on the synovial biopsy led to the diagnosis of Noonan-like/multiple giant cell lesion syndrome.