Biomedical subjects

L R Katta

Publications and source records attributed to L R Katta.

3 recordsLinked to original sources

PubMed1989

Triphasic Randomized Clinical Trial: Comparison of effects on carbohydrate metabolism.

One hundred thirty women were randomly assigned to treatment with one of three triphasic oral contraceptives and 43 women using nonhormonal methods served as controls for a 6-month study of the metabolic effects of these formulations. One of the oral contraceptives contained ethinyl estradiol and levonorgestrel, and the other two contained ethinyl estradiol and norethindrone. Compared with pretreatment assessment, all three triphasic oral contraceptives produced small increases in the mean plasma glucose levels that were statistically significant but clinically unimportant. No subjects had abnormal glucose response curves in glucose tolerance test results. Compared with pretreatment assessment, all of the oral contraceptive preparations produced small increases in the mean insulin levels at 3 months but not at 6 months. Overall there were no statistically significant differences among the three formulations in their effects on carbohydrate metabolism as measured by glucose or insulin levels after 6 months of treatment.

Blood Glucose↗

PubMed1989

Triphasic Randomized Clinical Trial: comparative frequency of intermenstrual bleeding.

Oral contraceptives have the highest theoretic efficacy of all reversible forms of contraception, yet in practice they have an actual failure rate equivalent to that of some barrier methods. The efficacy of oral contraceptives depends primarily on patient compliance. So-called "nuisance" side effects, such as intermenstrual bleeding (breakthrough bleeding or spotting), play a major role in their discontinuation. The Triphasic Randomized Clinical Trial compared the incidence of these side effects in three groups of subjects taking NET (A) (Ortho-Novum 7/7/7), LNG (Tri-Levlen), or NET (B) (Tri-Norinyl). Subjects taking NET (A) had the highest incidence of intermenstrual bleeding (63%) followed by NET (B) (44%) and LNG (33%). Only the difference between NET (A) and LNG attained statistical significance (p less than 0.030). Control subjects had no breakthrough bleeding and a 4% incidence of spotting. Further research is warranted to establish the cause of the disparity in the incidence of intermenstrual bleeding among patient groups assigned to the three oral triphasic contraceptives.

Contraceptives, Oral↗

PubMedDate not supplied

The isolation of Neisseria gonorrhoeae: a comparison of three culture transport systems.

Endocervical swabs for the culture of Neisseria gonorrhoeae from 417 patients attending a pelvic infections clinic were evaluated. Three swabs were obtained from each patient. One swab was plated directly onto Thayer-Martin medium and taken shortly thereafter to a microbiology laboratory for evaluation. A second swab was inoculated into modified Stuart's transport media and transported soon afterward to the hospital microbiology laboratory. The third specimen was plated onto Transgrow media and transferred according to routine transportation protocols to the Maryland State Health Department for evaluation. The prevalence of Neisseria gonorrhoeae infection in this population was 14.6% (61/417). The sensitivities of the direct plating and modified Stuart's systems with on-site evaluation were 87% (53/61) and 85% (51/61), respectively, while the sensitivity of Transgrow plating with off-site evaluation was only 64% (39/61). These findings argue against the use of a system of Transgrow plating and off-site processing of culture specimens to screen for infections with Neisseria gonorrhoeae.

Bacteriological Techniques↗