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L R Lawrence

Publications and source records attributed to L R Lawrence.

4 recordsLinked to original sources
PubMed1976

Research data integrity: a result of an integrated information system.

The toxicologic problems of today frequently require long-term, multidisciplinary experimentation involving large numbers of animals. In order to provide the extensive safety evaluation necessary to produce data that can be reasonably extrapolated to humans, automated research support systems have transcended the position of useful tools and have become an integral part of the total design of experimental protocols. For an automated information system to fully represent the reality of the experiment, it must be able to assure integrity, as well as provide for the storage, calculation, and retrieval of data values of the quality and quantity necessary for fulfilling protocol requirements. Guarantees against error and loss of data, in addition to flexibility and easy access, must be an inherent part of the system if the acceptance and condifence of the investigator are to be obtained. This paper discusses the criteria, philosophies, and benefits of integrated data systems that ensure integrity of toxicologic research support.

Computers↗
PubMedDate not supplied

NCTR computer systems designed for toxicologic experimentation. IV. Experiment information system.

The Experiment Information System (EIS) is a computerized data collection, maintenance, and reporting system for specified information values collected during the lifespan of animals assigned to toxicologic investigations at NCTR. The system records and/or controls experimental variables, which might ultimately affect the results, through the operation and integration of the Diet Preparation Subsystem (DPS), the Environmental Monitoring Subsystem (EMS), the Microbiology Subsystem (MBS), and the Chemistry Data Subsystem (CDS). The fifth component of the EIS, the Experimental Data Collection Subsystem (EDCS), is responsible for handling all data generated by, or attributed to, the animals from assignment until death or removal. Through integration of these five subsystems, the history of an animal while on study is recorded and stored for later recall. In addition, "routine" and "special" reports are made available through the system software which enables stringent control of the experiment by the Principal Investigator, Animal Husbandry, and NCTR Management.

Animals↗
PubMedDate not supplied

NCTR computer systems designed for toxicologic experimentation. I. Overview.

Established in 1971 by the Food and Drug Administration (FDA) and the Environmental Protection Agency (EPA), the National Center for Toxicological Research is committed to the study of long-term, low-dose effects of potentially toxic substances, including carcinogens. The Scientific Information Systems Division (SISD) facility provides logistic support for complex experiments involving large numbers of test animals. Animal population at the Center, including the breeding colony and animals on experiment, can be as high as 80,000. Each animal must be accounted for, fed and watered under strict control, and continually observed. From birth to final examination, an individual animal might have as many as 3,000 individual elements of information associated with it. This paper introduces a series of reports dealing with an integrated and comprehensive system of experiment planning and implementation (including information gathering, classification, analyses and reporting), employing state-of-the-art data processing techniques. This extensive use of computer technology has permitted the collection, proper classification, and rapid retrieval of virtually error-free data, resulting in cost-sensitive experiment planning.

Computers↗