Biomedical subjects

L R Menendez

Publications and source records attributed to L R Menendez.

5 recordsLinked to original sources

PubMed1992

Synovial sarcoma. A clinicopathologic study.

Twenty-five cases of synovial sarcoma were reviewed clinically, roentgenographically, and pathologically. The histopathology of each tumor was classified as either monophasic (19 cases) or biphasic (six cases). A soft-tissue mass was seen on roentgenography in 70% of patients; calcification was present in 15% of cases. Treatment included surgery, with or without radiation and/or chemotherapy. Fifteen patients remained disease free at an average of 7.5 years, one patient had pulmonary metastasis, and nine patients have died. The critical prognostic factor was adequate surgical margins; there were no local recurrences with adequate tumor-free margins, but there was an 83% recurrence rate with inadequate treatment.

Adolescent↗

PubMed1990

Neurofibroma in a patient with von Recklinghausen's disease seen as a malignant schwannoma. A case report.

A rapidly growing, malignant schwannoma occurred in a 46-year-old woman with neurofibromatosis. Computed tomography, isotope bone scan, chest roentgenogram, and angiogram are helpful in determining the local extent and distant spread of such musculoskeletal tumors and are useful in planning appropriate surgical management. A well-planned biopsy, however, is essential to accurately determine the histologic diagnosis of the tumor. Clinical and roentgenographic presentation of some benign lesions may mimic malignant tumors. To confirm the diagnosis of a malignant or benign tumor, it is advisable to examine the musculoskeletal tumor histologically before proceeding with the definitive treatment, even if the clinical presentation strongly suggests malignancy.

Diagnosis, Differential↗

PubMed1990

Malignant tumors of the upper extremity in children.

Of the 422 primary malignant tumors of bone and soft tissue treated at one institution between 1968 and 1988, the 29 found in the upper extremity in children are reviewed. In the latter group, there were 13 patients with osteosarcoma; one was lost to follow-up shortly after diagnosis, one was alive and disease free four years after surgery, two are currently being followed, and nine are dead. All of the four patients with Ewing's sarcoma died. Three patients had chondrosarcoma; one was lost to follow-up after surgery, and the other two were disease free at four and 14 years' follow-up. Two of the nine patients with soft-tissue sarcomas died as a result of their tumors.

Adolescent↗

PubMed1990

Fat embolism syndrome complicating intraarterial chemotherapy with cis-platinum.

A 19-year-old man with telangiectatic osteosarcoma of the left proximal femur was started on a course of neoadjuvant chemotherapy consisting of intraarterial administration of cis-platinum. Within 72 hours of receiving the first intraarterial dose, the patient developed signs and symptoms of fat embolism syndrome (FES). A physical examination revealed cyanosis, tachycardia, and seizure activity. Laboratory studies demonstrated a pO2 of less than 65 mmHg, lipuria, and a drop in hematocrit of three percentage points. There was no clinical or roentgenographic evidence of pathologic fracture. Tumor necrosis secondary to intraarterial cis-platinum therapy in this patient with osteosarcoma may have caused a sudden release of free fatty acids and embolization of fat macroglobules that precipitated this episode of FES. FES in association with the intraarterial administration of cis-platinum seems not to have been previously reported.

Adult↗

PubMed1988

Diaphyseal intraosseous ganglion.

Ganglion cysts of bone are noted to occur most often in the metaphysis of epiphysis of a long bone. A unique ganglion cyst, developing in a diaphyseal location, was excised from the leg of a 14-year-old boy. The follow-up examination showed no recurrence one year following surgery.

Adolescent↗