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L R Pisharodi

Publications and source records attributed to L R Pisharodi.

11 recordsLinked to original sources
PubMed1998

Diagnosis and differential diagnosis of small-cell lesions of the liver.

The objective of this study was to evaluate the cytologic spectrum of small cell lesions of liver as diagnosed by fine-needle aspiration (FNA). Of 304 FNAs of liver that were performed in our institution between 1990 and 1994, 29 were classified as small-cell lesions. The final diagnoses were as follows: small-cell undifferentiated carcinoma (10), neuroendocrine carcinoma (9), cloacogenic carcinoma (1), Merkel-cell carcinoma (1), cholangiocarcinoma (1), metastatic adenocarcinoma (4), small-cell sarcoma (1), lymphoma (2). Relevant clinical history and immunocytochemistry were helpful in making the final diagnosis in some cases. The diagnosis and differential diagnosis of small cell lesions of the liver are discussed in detail in this report.

Adenocarcinoma↗
PubMed1997

False-negative diagnosis in fine-needle aspirations of squamous-cell carcinoma of head and neck.

Squamous-cell carcinoma (SCC) is the most common malignancy encountered in the head and neck area. Fine-needle aspiration (FNA) is routinely performed in the diagnosis of primary, recurrent, and metastatic SCC. This paper describes several diagnostic problems and pitfalls that might be seen in FNAs of SCC. These include cystic changes, well-differentiated SCC, spindles SCC, and SCC with foreign-body giant cells, keratin plaques, and ghost cells. Recognition of these patterns along with clinical correlation enables the pathologist to prevent a false-negative diagnosis.

Adult↗
PubMed1996

Cytologic diagnosis of pseudomyxoma peritonei: common and uncommon causes.

Pseudomyxoma peritonei (PP) refers to accumulation of mucus in the peritoneal cavity, regardless of cause or pathogenesis. We have reviewed 8 cases of PP diagnosed in our institution over the past 5 years. Pertinent cytologic features include a mucinous background with mesothelial cells and histiocytes. Two cases contained rare clusters of neoplastic epithelial cells, with low-grade nuclear features of malignancy. The origin and nature of the parent neoplasms were variable, with no reflection of the cytologic features of PP.

Aged↗
PubMed1996

Cytopathology of serous neoplasia of the ovary and the peritoneum: differential diagnosis from mesothelial proliferations.

Serous neoplasia of the ovary ranges from benign adenomas through serous borderline tumors to invasive serous adenocarcinoma. This spectrum of neoplasia is at least partially reflected in the cytomorphologic features of the lesions. The objective of this study is to review the cytopathology of serous neoplasia of the ovary. In addition, cytologic features of serous surface papillary carcinoma and its distinction from peritoneal mesothelial proliferations are discussed.

Cystadenocarcinoma, Papillary↗
PubMed1995

Differential diagnostic dilemmas in malignant fine-needle aspirates of liver: a practical approach to final diagnosis.

We retrospectively reviewed two hundred malignant fine-needle aspirates of liver. Of these 49.5% were metastatic neoplasms, 32% were hepatocellular carcinomas, and 18.5% presented with diagnostic dilemmas. In less than half of these diagnostic challenges, differential diagnosis was between hepatocellular carcinoma and metastatic adenocarcinoma. The remainder of cases involved a variety of metastatic neoplasms. Cytomorphology in association with immunocytochemistry resolved the diagnostic problems in about half of the problematic cases. Three cases were undifferentiated and remained unclassifiable. We conclude that approximately 80% of malignant lesions of liver can be correctly diagnosed by thorough cytomorphologic analysis and good clinical correlation, and 20% pose differential diagnostic dilemmas.

Adenocarcinoma↗
PubMed1995

Basal cell adenocarcinoma of the salivary gland. Diagnosis by fine-needle aspiration cytology.

Basal cell adenocarcinoma of salivary gland is a relatively recently described neoplasm. Histopathologic features of these tumors have been published in the literature mainly in the form of case reports. This paper elaborates and describes the diagnostic fine-needle aspiration cytomorphology of two cases of basal cell adenocarcinoma of parotid gland, which, to the author's knowledge, has not been previously reported in the English literature. Fine-needle aspiration specimens in both cases contained cohesive, focally papillary, and filiform groups of neoplastic cells, which were highly reminiscent of basal cell adenoma on low power examination. Higher power, however, revealed significant cytologic atypia and mitotic activity. Differential diagnoses included basal cell adenoma, epithelial rich pleomorphic adenoma, myoepithelial lesions, small cell undifferentiated carcinoma, and metastatic carcinoma among others.

Adenocarcinoma↗
PubMed1994

Elastofibroma dorsi: diagnostic problems and pitfalls.

The diagnostic cytomorphologic findings in a case of elastofibroma dorsi are described in this report. The correct diagnosis was initially overlooked on fine-needle aspiration, and was subsequently made by open biopsy. Review of the FNA material, however, demonstrated scanty but diagnostic material. Cytologic examination revealed a mixture of fibroblasts, adipose tissue, and swollen lightly staining cyanophilic elastic fibers in a background of collagenous matrix. Cross sections of the elastic fibers had the typical serrated and globular appearance. These fibers stained positive with elastin stains. The cytomorphology of elastofibroma dorsi with diagnostic pitfalls and differential diagnostic dilemmas are discussed in this article.

Aged↗
PubMedDate not supplied

Low grade papillary adenocarcinoma of minor salivary gland origin. Diagnosis by fine needle aspiration cytology.

OBJECTIVE: To describe the diagnostic cytologic features of low grade papillary adenocarcinomas of minor salivary gland origin (LPA) along with its pertinent differential diagnostic entities. STUDY DESIGN: The study was based on a histologically confirmed case of LPA that recurred after multiple excisions. Fine needle aspiration (FNA) was performed during the most recent recurrence. RESULTS: Low-power examination showed geographic sheets and papillary groups of epithelial cells. Individual cells were medium sized, with scant cytoplasm, finely clumped chromatin and occasional prominent nucleoli. Pleomorphism was conspicuously absent. Differential diagnosis included cellular mixed tumor, basal cell adenoma, basal cell adenocarcinoma, low grade mucoepidermoid carcinoma and metastatic papillary carcinoma. CONCLUSION: LPA can be accurately diagnosed by FNA biopsy. However, the cytopathologist must entertain and exclude various differential diagnostic entities.

Adenocarcinoma, Papillary↗
PubMedDate not supplied

Spectrum of cytologic changes in pregnancy. A review of 100 abnormal cervicovaginal smears, with emphasis on diagnostic pitfalls.

OBJECTIVE: To review pregnancy-related changes in cervicovaginal smears and to distinguish them from neoplasia and dysplasia. STUDY DESIGN: One hundred consecutive abnormal cervicovaginal smears from pregnant women obtained during 1992-1993 were reviewed. Corresponding biopsies that were available were also reviewed for cytologic correlation. RESULTS: Sixty-one percent of cases showed inflammation changes, 21% contained low grade squamous intraepithelial lesion, and 9% had high grade squamous intraepithelial lesion. Diagnostic problems were encountered with decidual cells, Arias-Stella reaction and trophoblastic cells. CONCLUSION: Both the clinician and pathologist must be aware of diagnostic pitfalls and false positive diagnoses in pregnancy. Hence, it is extremely important that the clinician notify the pathologist about the pregnancy status of the patient.

Cervix Uteri↗