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Biomedical subjects

L Réthy

Publications and source records attributed to L Réthy.

30 records · Page 2Linked to original sources
PubMed1975

Further investigations about the passive transfer of sensitivity caused by anti-thymocyte serum.

Soluble materials were obtained from the spleens and thymuses removed from mice sensitized by anti-thymocyte serum or normal horse serum. These materials were administered to mice. In the mice thus treated, anaphylaxis was provoked by iv inoculation of serum. Irreversible shock did not occur. Reversible anaphylactoid symptoms occured among the animals treated with the supernatants of cells of sensitized animals, in case when these cells have been disrupted by osmotic shock.

Anaphylaxis↗
PubMed1975

The effect of enhancing factor on the immunity of mice against tetanus.

Enhancing factor was prepared from spleens of mice primed and reinjected with tetanus toxoid. The culture supernatant was separated by gel chromatography on Sephadex G-150, the resulted fractions were ultrafiltered and their enhancing activity was tested in vivo. The 1st fraction separated by gel chromatography proved to be active.

Animals↗
PubMed1975

Experiments for the production of graft-versus-host reaction in adult and infantile mice by means of human immunocompetent cells.

By administering anti-mouse ATS five times to random-bred Swiss albino mice weighing 16-18 and 10-11 g respectively, the authors have tried to produce immunological depression of such a degree which would allow living human leukocytes to cause GVH reaction. On the basis of the results it may be stated that with the serum dosage and manner of treatment applied, the human graft was not able to act against the recipient organism and to produce differences in body weight.

Aging↗
PubMed1975

Exeriments for the production of graft-versus-host reaction in newborn mice by means of human immunocompetent cells.

It was not possible to produce the wasting disease in newborn mice by administering human leukocytes in Hanks' solution, or suspended in m-ATS or h-ATS. The attempt of the authors to produce immunosuppression by the administration of m-ATS started at newborn age-as a result of which the human immunocompetent cells would have produced serious GVH reaction-resulted only in a trend of GVH. The authors used only body weight measuring for detecting the GVH reaction. More sensitive parameters will be employed in their experiments in progress.

Animals↗
PubMed1975

Experiments for producing specific immunological tolerance by intrauterinely administered immunocompetent human cells.

As a consequence of living human leukocytes administered intrauterinely on the 16th day of pregnancy, it was not possible to study the litter since it fell victim to cannibalism immediately after delivery. After the administration of sonically disintegrate leukocyte antigen healthy newborns were dropped. Living human leukocytes administered before the age of 2 day to mice treated in this way, produced no GVH reaction ascertainable with loss of weight but a considerable number of deaths occurred in comparison to the control. Further possibilities of studying the anti-human anti-thymocyte serum by means of cell chimeras are discussed.

Animals↗