[Carbon dioxide partial pressure gradient of the arterial blood and the end-tidal air sample in chronic bronchopulmonary diseases].
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Biomedical subjects
Publications and source records attributed to L Radwan.
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The results of a preliminary analysis on the role of lymphocyte count on prognosis of therapy outcome and influencing the decision to start therapy carried out on 21 patients with sarcoidosis are presented. The decision to commence treatment was carried out after BAL was performed but the results of it were not taken in account. The patients were observed for 7 to 33 months. The course of the disease was assessed basing on clinical, radiological and functional examination. In 6 patients a control BAL was carried out. The results allow to state that high lymphocyte BAL counts do not have to be poor prognostic factors. On the other hand low counts cannot predict a benign clinical course. In the discussion the authors evaluate, basing on literature data, the role of BAL in sarcoidosis.
A picture and clinical course of the acute and exacerbated chronic respiratory failure have been analysed. An analysis embraced a group of 49 patients, i.e. 16 percent of all patients treated at the Intensive Care Unit. Four subgroups were distinguished depending on the etiology of the disease in which infectious, thrombo-embolic, circulatory or toxic factors caused respiratory failure. An emphasis is on the prevalence of the infectious etiology of disease being noted in 65% of patients. Acute respiratory failure was observed in 37% of patients whereas exacerbation of the chronic respiratory failure in 63%. Complete respiration distress was noted in 55% of cases and partial respiratory failure in the remaining 45%. Gasometric differences characteristic for each subgroup of the patients have also been analysed. 41% of the patients died. The highest mortality rate was seen in pulmonary embolism complicating various pulmonary diseases. Sudden cardiac arrest, shock and not compensated acidosis have been most unfavourable factors in the prognosis.
We compared endoscopical signs of airway collapse seen during tidal breathing with the shape of the maximal-expiratory flow volume curve and selected functional parameters in 16 cases of chronic obstructive pulmonary disease (COPD). Depending on localization of airway collapse the group was divided into two. 12 patients with central collapse involving the trachea and main stem bronchi formed group A. The remaining 4 patients with peripheral collapse (lobar and segmental bronchi) formed group B. In the former group the MEFV curve had a characteristic biphasic shape. The shape of this curve in the group B patients was more curvilinear. In group A patients an increase of Raw, TGV and fall of FEV1 was seen which could not be demonstrated in group B. The biphasic shape of the MEFV curve seems to be characteristic of airway collapse, but due to a small number of patients included we can not assess the specificity of it in diagnosing airway collapse.
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