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Biomedical subjects

L Raimondi

Publications and source records attributed to L Raimondi.

At least 73 records · Page 4Linked to original sources
PubMed1983

Catalytic properties of serum albumin.

In this work it has been observed that human blood plasma is able to catalyse the reaction between tert.butyl hydroperoxide and 2-nitro-5-mercaptobenzoic acid. The purification of a proteic fraction responsible for this activity indicated it is due to plasma albumin; this is also demonstrated using various purified commercial albumins. We have determined the Vmax and the Km of the reaction and the effect of some substances of pharmacological or physiological importance on the same reaction. Some antiinflammatory non-steroidal drugs showed an inhibitory effect on the phenomenon, similar to that of endogenous substances such as fatty acids, bilirubin and arachidonic acid. The ability of other physiological substances such as cytochrome c, hemoglobin and hemin to catalyze the same reaction has also been observed.

Animals↗
PubMed1983

2-Phenylpyrazolo[1,5-a]pyrimidin-7-ones. A new class of nonsteroidal antiinflammatory drugs devoid of ulcerogenic activity.

Syntheses of some pyrazolo[1,5-a]pyrimidines were performed in order to study the relationship between structural modifications on the parent 4,7-dihydro-2-phenylpyrazolo[1,5-a]pyrimidin-7-one (1) and their antiinflammatory properties. The modifications carried out were introduction and functionalization of a longer side chain at the 4-position, substitution of the hydrogen atom at the 3-position, and replacement of the phenyl group with a 4-methylphenyl, methyl, or hydrogen substituent. 4-Ethyl-4,7-dihydro-2-phenylpyrazolo [1,5-a]pyrimidin-7-one (3) showed the highest activity and a better therapeutic index than phenylbutazone and indomethacin, used as reference drugs. All other changes at the 3-, 5-, and 6-positions, as well as the replacement of the phenyl group at position 2, caused a marked decrease of activity. Compound 3 was found devoid of ulcerogenic activity and was probably endowed with antiulcerogenic properties.

Animals↗
PubMed1983

The amine oxidase of human blood lymphocytes and granulocytes.

The deamination of some monoamines in human blood lymphocytes and granulocytes is dependent on the presence of two different enzymes: a mitochondrial (type B) monoamine oxidase and a "benzylamine oxidase" similar to the plasma BAO which is inhibited by semicarbazide and resistant to clorgyline.

Benzylamine Oxidase↗
PubMed1980

[Effect of 22Na on the zeta potential of malignant cells].

Membrane changes of Yoshida tumor ascites cells, "in toto" or centrifuged, were studied means of cytopherometric and istoautoradiographic techniques, by using various specific activities of 22 NaCl for different time intervals. This study shows the existence of a relationship between cellular membranes and cytoplasm labelled electrophoretic mobility and the Zeta potentials of the tumor cells. The presence of ascites liquid appears to be critical.

Animals↗
PubMed1980

3-Hydrazinopyridazine derivatives as inhibitors of pyridoxal-phosphate dependent enzymes.

A series 3-hydrazinopyridazine derivatives with anti-hypertensive properties was studied as inhibitors of pyridoxal-phosphate dependent enzymes. All the compounds with a free hydrazino group were found to be strong inhibitors in vitro. In vivo inactive compounds became active at doses which exert a hypotensive action. The significance of this inhibition is discussed.

Amine Oxidase (Copper-Containing)↗