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L Ratzmann

Publications and source records attributed to L Ratzmann.

5 recordsLinked to original sources
PubMed1978

[Changed body composition by increased total body fat content in experimentally hypothyroid rats].

Total body fat content was determined in growing normal male Wistar rats and hypothyroidized animals 7 weeks after feeding with Methimazol (group MMI-HT), Methyl-thiouracil (group MTU-HT), and performance of radiothyroidectomy by 131-iodine (group R-HT), respectively. At the end of experiments there was an extreme hypothyroid state in all treated groups, verified by external signs, growth kinetics, serum cholesterol estimation and evaluation of the iodothyrosine pattern of the thyroid glands. Changed body composition resulted in all HT-groups from significant increase of total body fat content. The relation of constituents fat : protein : water of 1 : 2 : 6 in the KT-group was changed into 1 : 1 : 3 in the HT-groups. No differences were found between the different HT-groups. Our findings are in good agreement with altered metabolism of plasma lipids described by other authors showing the existence of a highly disturbed lipid metabolism in thyroid hormone deficiency.

Animals↗
PubMed1977

[Effect of degree of experimentally induced hypothyroidism on changes in serum albumin spectra in rats].

Extreme rat hypothyreosis of identical degree was induced by radiothyroidectomy (group R-HT) and feeding of thyreostatics (groups MTU-HT and MMI-HT). External signs, growth kinetics, serum cholesterol, thyroid weight, and the iodothyrosine pattern of the thyroid glands served as references for the quality of the hypothyreotic state. Determinations of following changes (all changes significant for p less than 0.001): 1. Higher total serum protein levels in hypothyreotic rats 4 and 7 weeks after beginning the experiemnts as compared to the controls (KT). 2. After 4 weeks the relative albumin content was diminished, the relative gamma-globulin content was elevated as compared to the KT. The absolute values of albumines did not change, alpha-1-globuline and gamma-globuline contents were increased in all hypothyreotic groups. 3. After 7 weeks normal albumine values, increase of the relative and absolute alpha-1-globuline content, and decrease of the relative beta-globuline concentrations were measured. Elevated gamma-globulins were found in MMI-HT and R-HT only, and an increased absolute albumine content in MTU-HT alone. The results confirm both hyperproteinemia and dysproteinemia as characteristics of the rat hypothyreotic state. Dynamic changes of absolute and relative contents of different serum protein fractions are demonstrated in relation to the duration of hypothyreosis. This fact can possibly explain contradictory findings on type of dysproteinemia by several authors.

Animals↗
PubMed1975

[Deiodase activity in hypothyroid rats].

In rats hypothyroidized with methylthiouracil (MTU), methimazol (MMI), or radiothyroidectomy, the extent of deiodination for L-diiodotyrosine (L-DIT) and L-thyroxine (L-T4) was investigated in homogenate supernatants of liver and kidney. Deiodination in liver and kidney for DIT is twice as high as for T4, but the kidney allows only 25% of the liver deiodination activity both for DIT and T4. In the livers of all hypothyroid animals, iodide splitting both from DIT and T4 is highly significantly reduced by one-half compared with controls. In the kidney of all hypothyroid animals, the DIT deiodination is highly significantly lowered in comparison with controls; the T4 deiodination is significantly reduced only in animals treated with MTU and MMI, and is not significantly enhanced in radiothyroidectomized rats. Thus, there is no difference between MTU and MMI in the extent of deiodination for DIT and T4 in the homogenate supernatants of rat liver or kidney.

Animals↗
PubMed1975

[Deiodination in the kidney and thyroid function)].

In homogenate supernatants of kidneys of male rats the extent of deiodination of L-diiodotyrosine (L-DJT) and L-thyroxine (L-T4) was investigated in dependence on the thyroid function (hypo- and hyperthyroidized) and also in dependence on age. In rats hypothyroidized by loading with Methylthiouracil (MTU) or Methimazol (MMI) the deiodination for L-DJT and L-T4 was significantly reduced, in rats loaded with 40 mug T4 sc. for 10 days, the deiodination was significantly enhanced compared with untreated control animals. With advancing age (6 weeks, 3 or 12 month) the deiodination activity is highly significantly reduced. The results underline relations between thyroid gland function and deiodination activity in kidney.

Age Factors↗