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Biomedical subjects

L Reinhold-Richter

Publications and source records attributed to L Reinhold-Richter.

13 recordsLinked to original sources
PubMed1991

[Immunohistochemical studies of bronchial carcinoma using monoclonal antibody A63-C/A3].

An immunohistological study was undertaken, using paraffin sections of 22 cases of lung carcinoma and a number of reference tissue samples, to clear up the reactivity of A63-C/A63 monoclonal antibody (IgM) which was capable of identifying a carcinoma-associated carbohydrate antigen. Following neuraminidase pretreatment of those sections, positive response to the above antigen was produced by more than 90% of all bronchial carcinoma samples, notwithstanding the histological type involved (squamous-cell carcinoma or adenocarcinoma). Columnar epithelium of the bronchi, not involved in the neoplastic process gave a positive immunoreaction with the antibody A63-C/A3 in 64% of the cases.

Adenocarcinoma↗
PubMed1991

[Normal rabbit sera. An immunologic and immunohistologic study].

Reported in this paper are results obtained from immunological and immunohistochemical studies into non-immune rabbit sera which were tested for various antimycobacterial antibodies. 11% of the sera were found to be positive by transmigration electrophoresis, while antibodies against mycobacteria were recorded from 94% of all rabbits by peroxidase-antiperoxidase (PAP), an immunohistological technique of higher sensitivity. Several owners had kept rabbits together with fowl, which was considered to be one of the causes of very high contamination of rabbit stock with mycobacterial antigens. Antimycobacterial antisera and control sera should be obtained from animals with no record of natural immunisation against mycobacteria, since this is the only way to avoid falsely positive reactions, primarily to the use of the immunohistological PAP technique.

Animals↗
PubMed1989

[Quantitative-morphometric characterization of the lung structure in congenital heart defects exemplified by Fallot disease and isolated ventricular septal defect].

The aim of this study was to investigate the possibility of determination of lung changes in congenital deformity of heart and vessels by the method of Weibel and Elias (1967) for count of points in the lung (volume of alveoli and interstitium). The results show that this method is suitable for the estimation of quantitative changes in Morbus Fallot. In order to decide the degree of arteriosclerosis an additional measurement of the wall thickness of lung vessels is necessary in cases of ventricular septal defect. The arteriosclerosis is an important factor for the secondary variations, especially of the right heart. A field of application of this method could be the praeoperative lung biopsy for the clarification of the question of operability.

Adolescent↗
PubMed1989

[Ultrasound diagnosis of severe fetal abnormalities].

Reported in this paper is a case of premature termination of pregnancy in the 29th week because of sonographically diagnosed multiple malformations of the fetus. Holoprosencephaly, omphalocele, polyspleny syndrome, double-outlet right ventricle, and several skeletal malformations were established by pathologico-anatomic investigations. Possible correlation between these malformations are discussed in some details.

Abnormalities, Multiple↗
PubMed1988

[Architectonic characteristics of the heart ventricles in a perimembranous defect of the interventricular septum].

The results of quantitative morphological macro-, micro-, and ultrastructural (myocardial biopsies) studies of the ventricles with perimembranous septal defect in 135 infants under the age of one year have been compared. In newborns there appeared ventricular myocardial hyperplasia and low absolute and relative values of all the myocardial parameters versus normal control. At the age of 3 months the parameters were similar to or above the control ones exceeding them considerably by the age of 10-12 months. The comparison of the parameters of the septal parts showed predominant abnormality of the sinus part indicating that the perimembranous ventricular septal defect entity is a sinus one.

Cardiomegaly↗
PubMed1987

[Congenital heart defects. Frequency at autopsy].

Autopsies were performed on 3,071 stillborns and decreased children up to the age of 16 years at the Institute of Pathology of the Charité from 1969 to 1983. Congenital heart disease (CHD) was found in 814, i.e. 26.5% of the autopsies. Results of re-examination of 642 hearts with CHD are discussed. The most common malformations are ventricular septal defects, d-transpositions of the great vessels, tetralogy of Fallot and aortic coarctations. CHD was more frequently found in boys than in girls (1.5 : 1). The majority of the deaths occurred during the first year of life (78.8%). 20.1% of these took place during the perinatal period and 47.2% within the first 6 months of life. Additional cardiac anomalies were associated with the main defect in 81.8% of cases. The most common such associated defects were atrial and ventricular septal defects, aortic coarctations and other aortic arch anomalies. The frequency of extracardiac malformations in CHD was 7.2%. The most common anomalies were of the central nervous system, the gastrointestinal tract and the urinary system. Malformation syndromes were identified in 5.6% of the CHD cases, including Down's syndrome in 1.4%.

Adolescent↗
PubMed1984

[Extreme Ebstein's anomaly].

The incidence of Ebstein's anomaly among patients with congenital heart disease is about 0.5 and 1% among autopsy cases. Among 279 autopsy cases with congenital heart disease of the period from 1978 to 1982 we found 3 Ebstein's anomalies. The reported case is a rare combination of Ebstein's anomaly with ventricular L-loop, corrected transposition of the great arteries, atresia of aortic valve, hypoplasia of the aorta and of the aortic arch, coarctation of the aorta and septum secundum defect. Such a case has not been communicated in the literature. The case is described and the embryological development of the abnormalities is discussed.

Abnormalities, Multiple↗
PubMed1976

[Congenital laryngeal atresia with aplasia of trachea (author's transl)].

Case report of a rare congenital laryngeal atresia with aplasia of trachea and a large communication between bifurcatio tracheae and oesophagus in a 5 minutes old nearly mature male newborn. The formal pathogenesis of this abnormality is discussed by a short summary of the embryological development of larynx and trachea. This is the 16th case so far communicated in Literature.

Abnormalities, Multiple↗