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Biomedical subjects

L Resi

Publications and source records attributed to L Resi.

33 records · Page 2Linked to original sources
PubMed1976

Aortic endothelial and sub-endothelial lesions in early stages of experimental atherogenesis and in scurvy.

The endothelial and sub-endothelial lesions during early stages of experimental atherogenesis and scurvy have been studied by means of scanning EM and transmission EM, making use also of the Con-A reaction. The surface coat modifications were accompanied by formation of vacuoles in the endothelial cells and by sub-endothelial 'oedema', not only in rabbits fed a hypercholesterolic diet but also in scorbutic guinea pigs. The endothelial lesions were sometimes found even before clear modifications of the Con-A surface reactive layer were apparent.

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PubMedDate not supplied

Repair of early cholesterol-induced aortic lesions in rabbits after withdrawal from short-term atherogenic diet. Scanning electron-microscopical (SEM) and transmission electron-microscopical (TEM) observations.

Signs of repair of early atherosclerotic lesions after withdrawal of rabbits from a short-term atherogenic diet have been observed by means of scanning and transmission electron microscopy. The endothelial lining was lacking over large portions of the plaques during early atherogenesis. During the regression phase, hematic cholesterol values returned to normal, the smooth muscle cells of the plaques lost a large part of the lipids they had accumulated, while the surface of the plaques was covered by a continuous layer of endothelial cells.

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PubMedDate not supplied

Natural history of TCDD-induced liver lesions in rats as observed by transmission electron microscopy during a 32-week period after a single intraperitoneal injection.

Forty-two male rats were injected with a single intraperitoneal dose of TCDD in acetone and corn oil and sacrificed after 2, 4, 8, 16, 24, and 32 weeks, to study the long-term effects of a single injection. The liver lesions become progressively worse up to the 16th week and appear thereafter to slowly regress.

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PubMedDate not supplied

Some pathogenetic aspects of atherosclerotic lesions. Platelets and atherogenesis. Differences in atherogenesis in different body districts. Regression of arterial lesions in animal models.

The first part of the paper is devoted to the role of platelets in atherogenesis because the new ultrastructural techniques have revealed the morphological basis of platelet "activation". In the second part, the delayed involvement of intracranial vs extracranial cerebral arteries, afferent to the brain is examined on the basis of recent work both in man and in experimental animal models. Regression of arterial lesions is considered in the third part chiefly on the basis of contributions in experimental animals, while more data on regression in humans are expected in the near future.

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