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L Roels

Publications and source records attributed to L Roels.

46 records · Page 3Linked to original sources
PubMed1984

Prognostic factors in a transplantation center with good results.

In a homogeneous group of 299 first cadaver kidney allograft recipients transplanted within one single center between 1973 and 1983, we analyzed the influence of several factors on graft survival. All recipients received at least one blood transfusion before transplantation. Criteria of donor-recipient selection as well as immunosuppressive treatment policy have never changed significantly within the studied period. In contrast to matching for HLA-A and B antigens, DR-matching has a significant influence on early graft survival. Kidneys with zero DR-mismatches have a one year graft survival of 96.2% versus 75.6% for kidneys with 2 DR-mismatches (P less than 0.05). The presence or absence of DRW6 in the recipient as well as in the donor has no effect on graft survival. A preservation time less than 12 hours is accompanied by a decreased early graft survival. The long-term survival of kidneys from donors older than 30 years is significantly reduced. At 5 years graft survival of kidneys from donors younger than 30 years is 75% versus 53% for kidneys from donors older than 30 years.

Blood Grouping and Crossmatching↗
PubMed1983

Importance of HLA-DR matching in polytransfused cadaveric kidney transplant recipients. A prospective one-center study.

Since August 1978 prospective HLA-DR typing has been performed in 157 donor-recipient pairs. All recipients received pretransplant blood transfusions. This study shows that HLA-DR matching can significantly improve the survival of cadaveric kidney allografts, even in polytransfused recipients. Patients receiving kidneys with no HLA-DR incompatibilities have a one-year graft survival of 97%, versus 86% for recipients with 1 HLA-DR incompatibility and 73% for recipients with 2 HLA-DR incompatibilities. The cumulative dose of corticosteroids during the first year after transplantation is significantly lower in patients with no DR-incompatibilities. HLA-A and B matching have no additional effect on graft survival.

Adult↗
PubMed1976

Significance of urinary excretion of fibrin degradation products during treatment of glomerulonephritis.

189 patients with various types of glomerular disease were studied. Creatinine clearance, protein excretion and urinary excretion of fibrin degradation products (FDPs) were measured before and at various intervals (up to 42 months) after starting treatment with indomethacin, alone or in combination with other drugs. The following observations were made: a. Patients with a urinary FDP in excess of 2 mg/24 hours before treatment had a significantly lower creatinine clearance and a significantly higher protein excretion than patients excreting less than 2 mg FDP/24 hours, indicating that FDP excretion reflects the severity of the renal disease. b. During treatment, the incidence of high FDP excretion decreases progressively, but remains high in patients who ultimately develop renal insufficiency. c. There is no correlation between the initial value of FDP excretion and the subsequent changes in creatinine clearance and proteinuria during treatment. This implies either that the initial FDP excretion has no prognostic value or, perhaps more likely, that disease activity is modified by treatment. d. The best correlation between FDP excretion and evolution is found in proliferative glomerulonephritis. There are reason to suppose that, in this group at least, the treatment influenced the evolution of the disease.

Creatinine↗
PubMedDate not supplied

[Kidney preservation methods (author's transl)].

The results of preservation of the two kidneys of the same animal by two different techniques and then reimplanted on the same femoral artery, have been compared. The two methods are the following: 1) Short starting perfusion by Collins solution and than cold storage a 4 degrees C in the same solution. 2) Continuous perfusion by machine supplied by pulsatile pump, oxigenator, cooling. The first more impressive result by using continuous perfusion is the possibility of nullifying the effects of warm ischemia up to 30'. Kidney preservation with continuous perfusion is like to give less problems in the postoperatory period. Some weeks after transplantation however, the problems seems to increase in comparison with kidneys stored in Collins solution and not rarely sudden GFR decreases or anurias without immunologic rejection has been observed. Cautious conclusion should advise to use Collins solution when there has not been a long warm ischemia.

Animals↗