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Biomedical subjects

L Ros

Publications and source records attributed to L Ros.

6 recordsLinked to original sources
PubMed2001

Early detection of impaired glucose tolerance in patients with cystic fibrosis and predisposition factors.

INTRODUCTION: The number of patients with glucose tolerance alterations associated with cystic fibrosis (CF) has increased, probably due to the greater survival rate among sufferers of this disease. We studied impaired glucose tolerance (IGT) in patients with CF and investigated whether its appearance has any relationship with age, sex, genetic mutation and/or the degree of clinical involvement. We assessed the parameters that might allow early detection. PATIENTS AND METHODS: In 28 patients with CF (14 M, 14 F; aged 22 months to 18 years), sex, genetic mutation, nutritional status and the degree of pancreatic and pulmonary involvement were recorded. The metabolic study included glycosylated hemoglobin (HbA1c) determination, oral glucose tolerance test (OGTT) and intravenous glucose tolerance tests (IVGTT). RESULTS: In the patients with CF, 35.71% showed impaired glucose tolerance (IGT) and 3.57% had diabetes mellitus. The patients with IGT and CF were 3.2 years older than those with normal glucose tolerance (NGT; p<0.05), but no significant differences were found regarding sex, anthropometric measurements, percentage of pulmonary gammagraphic involvement, Shwachman-Kulczycki test or HbA1c. In the OGTT, the patients homozygous for the deltaF508 mutation had higher blood glucose values than the heterozygous group (p=0.03), but these values were not higher than those in patients with other mutations. During the OGTT, blood insulin values at 30' were reduced in patients with IGT compared to patients with NGT (p<0.02) and the insulin peak occurred at 100.9+/-24.3 min compared to 65.3+/-21.8, respectively (p<0.05). In the IVGTT, 82.14% of the patients had reduced insulin levels at 1 and 3 min (I1'+3'). No differences in the blood glucose levels during the OGTT were found between patients with normal I1'+3' values and patients with reduced values. CONCLUSIONS: A high percentage of patients with CF also present with IGT. This increases with age and is more common among patients homozygous for the deltaF508 mutation and is not related to clinical status. Alterations in the kinetics of insulin secretion play an important role in the appearance of IGT and CF. We suggest that the OGTT is a more sensitive method than IVGTT for identifying early alterations in CF-related diabetes mellitus.

Administration, Oral↗
PubMed1998

Quantitative measurements of the spinal cord and canal by MR imaging and myelography.

There is a large individual variation in human spinal cord and canal size, even in patients of different series studied by the same modality, and no authorized standard method has been established. A comparative study of sagittal diameters of the cervical spinal cord and canal using myelography and MRI is presented. The purposes of this paper are (a) to establish the correction factor (CF) needed for quantitative comparison of the two imaging modalities, and (b) to determine the different factors that may modify the measurement of these diameters. We studied 45 patients with clinical findings compatible with cervical spondilotic myelopathy. In our experience, the CF for accurate correlation of MRI and myelography measurements is 1.32 and depends almost entirely on the radiographic geometry of the myelographic procedure. In addition, there is a variability in the group of MRI results due to imprecision of the pressure-pad measuring/input device of the instrument itself and the sequence performed.

Adult↗
PubMed1996

[Multiple radicular tumors in von Recklinghausen disease assessed by magnetic resonance].

We present a case of multiple neurofibromata at lumbar nerve root level in a patient diagnosed as having Von Reckling-hausen's disease or type 1 neurofibromatosis (NF 1), studied using magnetic resonance (MR). We also observed in the same study the presence of dural ectasis, something likewise related to NF 1. We assessed MR possibilities in the study of this type of pathology and its relative advantages with respect to other types of image-forming techniques. MR is nowadays considered as the technique of choice when studying medullar and radicular pathology in patients suffering Von Recklinghausen's disease.

Adult↗
PubMed1995

Health record problem-oriented information system.

Health Record refers to the recording of the medical and relevant social history of the patient, obtained directly or indirectly. It is an instrument of frequent use that must guarantee the quality of assistance provided, reflecting all information pertinent to forming the patient's medical history. It must be designed so that data is easily and effectively retrieved for everyday use, without compromising the patient's privacy. The Health Record Problem Oriented model achieves all of these objectives. This model comprises: 1. Initial data: the relevant medical histories and biography is recorded. 2. Problems list: the patient provides reasons why she is seeking medical attention. 3. Performance plans: these include diagnostic, therapeutic, pharmacological, dietetic, physiotherapist, and surgical plans, as well as the education of the patient. 4. Evolution notes: the progress of the condition. This model guarantees multi-professional registration, an integral focus on the health, and a continued focus on the patient. These characteristics make it the model par excellence of Primary Care. Prior to the implementation of this model, existing information must be analyzed so that it can eventually be converted to a relational database. The Entity-Relationship Model (E/R Model) has been used to represent the database. Here, the basic concepts involved are entities, relationships, and attributes. Entities represent classes or objects from the real world that have common characteristics. The relationships represent the aggregation of two or more entities. The attributes are elemental properties of both entities and relationships. The E/R Diagram graphically represents the conceptual model of a database; the one built for the Health Record Problem Oriented reflects all the entities that compound the attending processes and the relationships existing between them. The Patient is the central axis of the attending process. The record contains the identifying data of the subject and his habits. We can know his medical history by means of his past Illness (personal and family record), Vaccine (what he is vaccinated against), and Case History (each patient has a case history). The other important component is the Consult Motive. A patient has a reason for every consultation, and this reason is added to her medical history as part of the Consult Motive. Each consult motive produces different events that are shown as relations with the other entities. So, for example, by analyzing a patient's history of complaints, a doctor can more suitably determine if she should recommend Cardiac or Anthropometric Exploration, request an Analysis, request a Radiography or Specialist Report, or prescribe a Treatment. The various elements that are part of a Consult Motive are expressed as different entities. Once the conceptual schema of the database is defined, the next step is to convert this schema to a logical schema, suitable for the Relational Model.

Medical Records Systems, Computerized↗
PubMed1995

Modeling medical services resources with the support of simulation tools.

Most Spanish General Hospitals record their patients in the Patient Registration Service; it is the first point of contact between patients and the General Hospitals. This service is in charge of planning the hospital activity; for management personnel it is fundamental to have such information available. Developing these models allowed managers to focus on the relevant points of the hospital.

Computer Simulation↗