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Biomedical subjects

L Rosenbaum

Publications and source records attributed to L Rosenbaum.

15 recordsLinked to original sources
PubMed1995

Biochemical quantification of triamcinolone in subconjunctival depots.

OBJECTIVE: To biochemically quantify the amount of active triamcinolone acetonide remaining after subconjunctival administration and to assess the effectiveness of surgical management for glaucoma induced by triamcinolone. DESIGN: Case series. PARTICIPANTS: Seven eyes of seven patients whose ages ranged from 47 to 84 years underwent excision of depot triamcinolone. Six of seven eyes required surgical intervention for medically unresponsive intraocular pressure (IOP) elevation. RESULTS: Pharmacologically active triamcinolone was identified up to 13 months following injection (range, 3 to 13 months). The mean amount in the excised sample was 5.4 mg (range, 2.0 to 8.8 mg), and the mean percentage of the original sample remaining was 20% (range, 4.2% to 44%). Glaucoma was diagnosed a mean of 3 months after injection (range, 1 to 6 months). Mean IOP was 37 mm Hg before excision and 16 mm Hg after removal. Surgical excision of visible triamcinolone normalized IOP in six of seven patients without need for glaucoma medications. CONCLUSIONS: Periocular injection of triamcinolone necessitates careful monitoring of IOP. Medically unresponsive IOP elevation may occur as late as 6 months following periocular triamcinolone injection. Surgical excision of remaining triamcinolone depot is an effective therapy for IOP elevation. Guidelines for safely using triamcinolone are discussed.

Aged↗
PubMed1994

A victimization assessment tool: instrument development and clinical implications.

Although most health care providers now recognize the importance of crisis intervention, support, and/or treatment for survivors of violence and abuse, such care is compromised unless early detection becomes a routine part of intake and assessment protocols in nursing and other facets of health care. This paper describes the development of a tool to assist nurses and other primary care providers with routine assessment for victimization in diverse health and mental health settings. It includes outcomes of preliminary validity and reliability studies, and concludes with suggestions for use in clinical work with victims/survivors of abuse in an era of increasing international concern regarding the health implications of violence.

Adolescent↗
PubMed1993

Intravascular immunoglobulin crystalloids in monoclonal cryoglubulinemia-associated dermatitis: ultrastructural findings.

A 46-year-old woman developed polyarthritis, purpuric skin rashes, nasal septal perforation and marginal furrowing of corneas in 1980. Monoclonal IgG, kappa cryoglobulinemia was found in the patient's serum. No underlying lymphoproliferative disorder has been found in ten years since her original diagnosis. In 1991, she developed palpable purpura on both lower extremities with subsequent necrosis and ulceration. A skin biopsy revealed fibrin thrombi within capillaries in the papillary dermis, and immunofluorescence studies showed IgG and light chain kappa within the fibrin thrombi. An electron microscopy study showed intravascular immunoglobulin crystalloid structures with a mean diameter of 80.3A degrees (8.03 nm), mixed with fibrin and red blood cells. The exclusive vascular location of these crystalloids may have implication in the pathogenesis of skin lesions.

Biopsy↗
PubMed1983

Biofeedback-assisted stress management for insulin-treated diabetes mellitus.

Six insulin-treated diabetic patients (four with type I and two with type II) who completed a biofeedback-assisted stress management program based on family systems theory improved their response to life stressors, and none had negative side effects. Four decreased their insulin requirement, including one who remained stable even during two pregnancies; the sixth became stable and discontinued drug abuse. All started biofeedback for reasons other than diabetes. Follow-ups of some individuals extend over 4 years.

Adolescent↗
PubMed1983

Effect of agents which block steroid receptor-DNA interaction on anti-DNA antibody titers in sera of patients with systemic lupus erythematosus.

We studied whether agents capable of blocking the interaction between steroid receptors and DNA could inhibit the serologic reactivity of anti-nuclear, and other, autoantibodies found in sera of humans with autoimmune disease. Conventional immunofluorescence procedures were used for both detection and titration of these autoantibodies. Parallel studies were conducted with sera diluted in buffers containing the inhibitory agents; KCl, Na2MoO4 or 1,10-phenanthroline, at optimal or suboptimal levels for blocking the steroid receptor-DNA interaction. In most cases these agents had no significant effect on the titer of autoantibodies present in human sera. However, there was one notable exception, that of autoantibodies to native DNA found in sera of patients' with systemic lupus erythematosus and detected by indirect immunofluorescence using Crithidia luciliae kinetoplast DNA as substrate. Here these agents caused either total inhibition of serologic reactivity at optimal blocking concentrations, or a significant reduction in titer, in all twelve specimens studied. These results give rise to at least two possible interpretations: (1) antibodies to native DNA are unusual with respect to the ease with which their binding to antigen may be inhibited by these three chemically unrelated compounds, and (2) steroid receptors are somehow involved in the binding of these antibodies to native DNA.

Animals↗
PubMed1981

Ongoing assessment: experience of a university biofeedback clinic.

The purpose of this paper is to assess the Georgetown University Family Center Biofeedback Clinic in its first 2 years of operation. The clinic used Budzynski's and Stoyva's training routines as well as family systems theory. Details of the treatment methods and the patients seen are described, along with an ongoing procedure developed to assess results. Preliminary results on 93 patients show that 80% report symptom improvement. Self-report of improvement is associated with decreases in frontal EMG levels and with changes in life-style.

Biofeedback, Psychology↗
PubMed1979

Upper airway obstruction as a complication of oral anticoagulation therapy. Report of three cases.

While taking orally administered anticoagulants, three patients had hemorrhages into their retropharyngeal and submandibular spaces, suffering eventual acute airway obstruction. One of the patients died. Despite the life-threatening nature of this complication of anticoagulant therapy, the diagnosis was obscure and initially veiled in complaints of sore throat or hoarseness, suggesting infection. Thorough investigation of such complaints is necessary in patients receiving anticoagulation therapy. If a hematoma is discovered, the patient should be admitted to the hospital for close observation and prompt reversal of anticoagulation with plasma. Intubation or tracheostomy also may be required.

Airway Obstruction↗