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Biomedical subjects

L Roth

Publications and source records attributed to L Roth.

87 records · Page 5Linked to original sources
PubMedDate not supplied

Temporary bile diversion in cats with experimental extrahepatic bile duct obstruction.

The use of a cholecystostomy catheter for temporary bile diversion was investigated in four cats with experimentally induced extrahepatic bile duct obstruction. Eighteen days after ligation of the common bile duct, a 6.5 F accordion catheter was placed in the gallbladder with a 22 g Hawkins needle-guide system through a paracostal incision. Biochemical parameters and fasting serum bile acids were monitored for 16 days. There were significant decreases in mean total bilirubin, aspartate aminotransferase, and fasting serum bile acids within 72 hours of bile diversion, and in mean alanine aminotransferase within 96 hours. Attitude and appetite improved, and the catheter was tolerated well. Positive bile cultures developed in three cats. Histologic changes in the gallbladder included mucosal ulcerations, a mixed inflammatory cellular infiltration, and fibrosis of the submucosa.

Alanine Transaminase↗
PubMedDate not supplied

Hepatic lobe torsion as a cause of colic in a horse.

A 14-year-old Arabian gelding was examined for colic. An exploratory celiotomy was subsequently performed and the left lobe of the liver was found to be twisted. The lobe was resected using a TA-90 surgical stapling instrument. Histologic examination of the resected liver indicated portal vein and sinusoid dilation and congestion with blood. There were focal areas of necrosis and bacterial cocci and rods throughout the section. The histologic findings were consistent with hepatic lobe torsion. After surgery, the horse was treated with broad spectrum antibiotics, anti-inflammatory drugs, heparin, and intravenous fluids. The horse recovered without complications, although serum liver enzymes remained elevated for more than 1 week after surgery. Seven months after surgery the horse showed no adverse affects from the disease.

Animals↗
PubMedDate not supplied

Hemolytic uremic syndrome in dogs.

A disease syndrome similar to the hemolytic uremic syndrome of people is described in three dogs with acute renal failure. In each dog, hemorrhagic gastroenteritis preceded the onset of anuric acute renal failure. Evidence of microangiopathic hemolytic anemia (schizocytes, thrombocytopenia, and increased concentrations of fibrin split products) was present in the three dogs. Serum chemistry results showed increased concentrations of blood urea nitrogen, creatinine, and phosphorus. Ultrasound examination performed in one dog revealed increased echogenicity of the renal cortices. Treatment for anuric acute renal failure using a continuous dopamine and furosemide infusion established urine production in one of three dogs. Microscopic examination of tissue from the two dogs that underwent necropsy showed occlusion of the renal vasculature by fibrin thrombi consistent with microangiopathic arteriolar thrombosis. The pathophysiology and current knowledge of human hemolytic uremic syndrome is compared with hemolytic uremic syndrome in these dogs.

Acute Kidney Injury↗
PubMedDate not supplied

The role of vaccinia virus in the evolution of some human hemopathies.

Six cases of severe hemopathy, detected following smallpox revaccination are described. Their onset was favoured by vaccinia virus-induced suppression of cell-mediated and humoral immunity. In two leukemia patients humoral immunity was present, but insufficient to assure protection of the diseased organisms, the outcome being fatal. The pancytopenia syndrome recorded in 4 patients with anergy caused by autoimmune mechanisms had different outcomes: favourable in 2 cases and fatal in the other 2 patients, who died within 4 years.

Hematologic Diseases↗
PubMedDate not supplied

Cancer screening in the community. Taking the show on the road.

PURPOSE: The authors describe the efforts involved in improving cancer screening of an underserved population using a mobile clinic to bring these services to the community. The background, methods, results, and implications are discussed, as are the logistics of packing, scheduling, and providing follow-up. OVERVIEW: Members of the University of Pittsburgh Cancer Institute Cancer Prevention and Early Detection Program developed a cancer screening program to serve the underserved communities in the Pittsburgh area. The African American Cancer Screening Program has presented the staff with significant challenges. The most significant of those challenges has been taking the most comprehensive screening program to the areas convenient to clients. Although coordinating staff, materials, and transportation was a challenge, the logistical problems involved were resolved, allowing for the opportunity to "take the show on the road". CLINICAL IMPLICATIONS: Because the mortality rate from some cancers is higher in black Americans, early cancer screening and detection is crucial in this population. The establishment of a mobile cancer screening clinic allows underserved communities access to these services. The physical screening, educational counseling, scheduling of mammographies and flexible sigmoidoscopies, and meticulous follow-up provided through the mobile clinic may lead to a greater awareness and reduced morbidity and mortality from cancer in these communities.

Black or African American↗