PubMed Health⌕ Search

Biomedical subjects

L Rubin

Publications and source records attributed to L Rubin.

At least 73 records · Page 4Linked to original sources
PubMed1984

Is homelessness a mental health problem?

Seventy-eight homeless men, women, and children staying at an emergency shelter were interviewed. The vast majority were found to have severe psychological illnesses that largely remained untreated. Approximately 91% were given primary psychiatric diagnoses: About 40% had psychoses, 29% were chronic alcoholics, and 21% had personality disorders. Approximately one-third had been hospitalized for psychiatric care. The authors discuss the relationship of mental health policy to the homeless and suggest that shelters have become alternative institutions to meet the needs of mentally ill people who are no longer cared for by departments of mental health.

Adolescent↗
PubMed1984

Delayed hyphema after argon laser iridectomy.

A 77-year-old black woman without neovascularization developed spontaneous hyphema two days after laser iridectomy. Bleeding originated at the site of iridectomy. This complication has not been previously reported.

Aged↗
PubMed1980

The effect of varying the temporal distribution of conditioning trials on equine learning behavior.

Two experiments were conducted to study the effect of varying the temporal distrbution of conditioning sessions on equine learning behavior. In the first experiment, 15 ponies were trained to clear a small hurdle in response to a buzzer in order to avoid a mild electric shock. Three treatments were used. One group received 10 learning trials daily, seven times a week; one group was trained in the same fashion two times a week and one group was trained once a week. The animals conditioned only once a week achieved a high level of performance in significantly fewer sessions than the ones conditioned seven times a week, although elapsed time from start of training to completion was two to three times greater for the former group. The twice-a-week group learned at an intermediate rate. In the second experiment, the ponies were rearranged into three new groups. They were taught to move backward a specific distance in response to a visual cue in order to avoid an electric shock. Again, one group was trained seven times a week, one group was trained two times and one group was trained once a week. As in the first experiment, the animals trained once a week achieved the learning criteria in significantly fewer sessions than those trained seven times a week, but, as in trial 1, elapsed time from start to finish was greater for them. The two times-a-week group learned at a rate in-between the rates of the other two groups.

Animals↗
PubMed1980

Amelioration of decompression sickness in mice by pretreatment with cyproheptadine.

Substances that stimulate smooth muscle have been previously implicated in the pathogenesis of decompression sickness. This concept was strongly supported by the demonstration that compounds that combine activities against histamine, bradykinin, and serotonin prevent or ameliorate decompression sickness. This communication deals with the prophylactic effect of cyproheptadine (Periactin), a drug exhibiting such pharmacologic properties. More than 500 obese mice were used. Experimental groups, subcutaneously injected with cyproheptadine (0.5-40 mg/kg) prior to compression, and corresponding control animals were simultaneously subjected to 75 psig air pressure for 6 h and then rapidly decompressed. Most control animals exhibited signs of decompression sickness (chokes, scratching, twitching, convulsions, paralysis) and died. Gross and histologic examination revealed gas bubbles in vessels and tissues, perivascular edema, and other changes. In cyproheptadine-treated animals the incidence and severity of clinical manifestations and pathologic alterations were reduced, and mortality was marked decreased. Statistically significant results were obtained with doses of 2.5-10.0 mg/kg. The 5-mg/kg does lowered mortality by 45.9%. These results support the proposed pathogenetic concept and suggest a potential preventive treatment for human subjects.

Animals↗
PubMed1976

A specific population of gonadotrophs purified from immature female rat pituitary.

When dispersed pituitary cells from 14-day-old female rats were sedimented in a bovine serum albumin gradient, a fraction was isolated which consisted of almost 90 percent of large cells that stained purple in the periodic acid-Schiff (PAS) reaction. Immunostaining indicated that over 85 percent of these PAS-purple cells were gonadotrophs containing both follicle stimulating and luteinizing hormone. Reproducible cell cultures could be obtained on poly-L-lysine coated dishes. As early as the second day in culture, the secretion of both follicle stimulating and luteinizing hormone was highly stimulated by luteinizing hormone-releasing hormone. The effect of FSH was as marked as that on LH. The data suggest that the isolated gonadotrophs are a specific functional subtype.

Age Factors↗