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Biomedical subjects

L S Khoo

Publications and source records attributed to L S Khoo.

5 recordsLinked to original sources
PubMed2000

Tetracycline and nicotinamide for the treatment of bullous pemphigoid: our experience in Singapore.

AIM OF STUDY: To study the efficacy of tetracycline (or doxycycline) and nicotinamide in the treatment of less extensive bullous pemphigoid. METHODS: An open trial of 11 patients with bullous pemphigoid. Treatment was initiated with tetracycline 1.5-2 g/day and nicotinamide 1.5-2 g/day and gradually tapered down. Doxycycline was substituted for tetracycline in patients who could not tolerate tetracycline due to gastrointestinal side effects or headache. RESULTS: 6 out of 11 patients achieved complete response (> 90% decrease in lesions) while another 2 had partial response (50-90% decrease in lesions). CONCLUSION: Tetracycline/doxycycline and nicotinamide is a useful alternative treatment for localized bullous pemphigoid, especially in those whose concurrent medical illnesses preclude the use of systemic corticosteroids.

Aged↗
PubMed1999

The clinical features and management of actinic prurigo: a retrospective study.

Actinic prurigo (AP) is a rare photodermatosis, mostly affecting young American Indian girls. A retrospective descriptive study was done in the National Skin Centre, Singapore. Our patients have different characteristics compared to the previous reports. Of the 11 cases found between 1990 and 1998, 10 were male. All of the patients had the onset in adulthood. The condition was recognised by the presence of papules and nodules on the sun-exposed areas, predominantly on forearms and back of hands. Phototests revealed lowered minimal erythemal dose (MED) to ultraviolet A (UVA) alone in 2 patients and lowered MED to both UVA and UVB in another 4 patients. Patch, photopatch and histological examination did not show any significant finding. Sun protection, emollients and topical steroid were the baseline treatment for all patients. Intralesional steroid, systemic steroid, psoralen plus ultraviolet A (PUVA), azathioprine and thalidomide were used in some patients, with variable results.

Adult↗
PubMed1996

A study of treponema pallidum haemagglutination positive blood donors in Singapore.

The Treponema Pallidum Haemagglutination (TPHA) test has been used for screening of syphilis among blood donors in Singapore since September 1992. Among the 79 500 donations that were screened between September 1992 and December 1993, 191 were tested positive (incidence rate of 0.24%). Seventy-two donors (37.7%) were evaluated at the Department of Sexually Transmitted Disease Control clinic. Seventy-nine percent of these donors had high risk sexual exposure and 33.3% had a history of sexually transmitted diseases. Eighty-three percent of the donors were diagnosed to have late latent syphilis, 9.7% were diagnosed to have a serological scar and the remaining had secondary syphilis, early latent syphilis and a false positive reaction. At least 65.3% of these donors would have been missed if the reagin test was used alone as the screening test. Thus, the TPHA test is a good marker for screening those who have high risk sexual behaviour and it is a more sensitive test than the reagin test for screening blood donors.

Adult↗
PubMed1995

Common genital dermatoses in male patients attending a public sexually transmitted disease clinic in Singapore.

The male genitalia is a common site of various dermatoses. Male patients attending a sexually transmitted disease (STD) clinic may present with dermatoses that are not due to sexually transmitted diseases. A prospective study on 467 male patients attending a public STD clinic showed various dermatoses which were either anatomical variants (pearly penile papules in 67 patients [14.3%], sebaceous hyperplasia in 16 [3.4%], Tyson's glands in 32 [7%] and penile melanosis in 13 [2.8%]) or pathological conditions (balanitis in 45 [9.6%], eczema in 10 [2.1%], traumatic ulcers in 10 [2.1%], folliculitis and furunculosis in 8 [1.7%], scabietic nodules in 7 [1.5%], genital candidiasis in 7 [1.5%] and a few miscellaneous conditions). Fifty percent of the patients with Tyson's glands also had pearly penile papules. Most of the anatomical variants were incidental findings whereas most patients with the pathological dermatoses presented with these lesions. Unfamiliarity with these dermatoses may cause unnecessary anxiety to the patient and physician, resulting in inappropriate treatment.

Adolescent↗